Studies on the Expression and Functions of RLIP76 in Blood Samples of Healthy Human Subjects
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 试验地点
- 1
- 主要终点
- Expression of RLIP76 in red blood cells and white blood cells of 100 healthy human subjects.
研究概览
简要总结
RLIP76 (Ral binding protein1) is a 76 kDa splice variant protein encoded by the human gene (RALBP1, 18p11.22). It is a multifunctional modular protein found ubiquitously from Drosophila to humans, in cells ranging from red blood cells to endothelial cells of the brain. Its expression more predominant in breast, heart, liver and less so in colon and brain parenchyma.
详细描述
RLIP76 is shown to be over expressed in a variety of cancer cells. However, no study has yet been done on its expression on normal cells. The studies proposed in this project will study the expression of RLIP76 in blood cells of healthy human subjects in the population of North Texas region.
研究设计
- 研究类型
- Observational
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy as defined by lack of serious health conditions or diseases
排除标准
- •Children, pregnant women, prisoners, persons with any medical condition that precludes phlebotomy and persons unwilling or unable to provide consent will be excluded.
结局指标
主要结局
Expression of RLIP76 in red blood cells and white blood cells of 100 healthy human subjects.
时间窗: 3 years
次要结局
- To investigate the RLIP76 mediated transport of glutathione conjugates and chemotherapeutic drugs.(3 years)