HLA-matched PT/CY
Phase 1
- Conditions
- AML, ALL, NHL, MDS
- Registration Number
- JPRN-jRCTs031180140
- Lead Sponsor
- Chiba Shigeru
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Recruiting
- Sex
- All
- Target Recruitment
- 20
Inclusion Criteria
1) AML, ALL, NHL, MDS
2) age 16-60
3) possessing allele 8/8 matched donor (age 16-60)
4) PS =< 2
5) EF >= 40%
6) SpO2 >= 90%
7) %VC >= 70% and FEV1.0% >= 70%
8) Bil =< 2.0 mg/dl
9) Ccr >= 30 ml/min
Exclusion Criteria
1) positive for HBs Ag
2) positive for HIV Ab
3) depression
4) pregnancy
5) coexisting active cancer
6) active infection
7) pentostatin administration
8) hypersensitivity to cyclophosphamide
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Success rate at 6 months.
- Secondary Outcome Measures
Name Time Method engraftment<br>acute GVHD (grade 2-)<br>chronic GVHD<br>non-relapse mortality