Clinical Trials
31
Trial Phases
4 Phases
Drug Approvals
0
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Clinical Trials
Distribution across different clinical trial phases (16 trials with phase data)• Click on a phase to view related trials
A Platform Protocol to Investigate Post-Transplant Cyclophosphamide-Based Graft-Versus-Host Disease Prophylaxis in Patients With Hematologic Malignancies Undergoing Mismatched Unrelated Donor Peripheral Blood Stem Cell Transplantation
- Conditions
 - AML (Acute Myelogenous Leukemia)Acute Lymphoid Leukemia (ALL)Acute Leukemia (Category)MDS (Myelodysplastic Syndrome)CML (Chronic Myelogenous Leukemia)CLL (Chronic Lymphocytic Leukemia)Prolymphocyctic LeukemiaChronic Myelomonocytic Leukemia (CMML)Myeloproliferative Neoplasm (MPN)Lymphoma
 
- Interventions
 - Drug: Conditioning Regimen ADrug: Conditioning Regimen BDrug: Conditioning Regimen CDrug: Conditioning Regimen DDrug: Conditioning Regimen EProcedure: Hematopoietic Cell TransplantationDrug: PTCy (50 mg/kg D3, D4)Drug: PTCy (25 mg/kg D3, D4)Drug: Post-transplant TacrolimusDrug: Post-transplant Mycophenolate mofetilDrug: Post-transplant AbataceptDrug: Post-transplant RuxolitinibOther: Study treatment complianceOther: Prohibited Concomitant TherapyOther: Permitted Concomitant Therapy
 
- First Posted Date
 - 2025-03-05
 
- Last Posted Date
 - 2025-09-10
 
- Target Recruit Count
 - 358
 
- Registration Number
 - NCT06859424
 
- Locations
 - 🇺🇸
Stanford, Palo Alto, California, United States
🇺🇸MD Anderson, Houston, Texas, United States
🇺🇸University of Virginia, Charlottesville, Virginia, United States
 
HLA-Mismatched Unrelated Donor Peripheral Blood Stem Cell Transplantation With Reduced Dose Post Transplantation Cyclophosphamide GvHD Prophylaxis
- Conditions
 - Acute Myeloid LeukemiaMyelodysplastic SyndromesChronic Myeloid LeukemiaChronic Lymphocytic LeukemiaChronic Myelomonocytic LeukemiaAcute LeukemiaPro-Lymphocytic LeukemiaAcute Lymphoblastic LeukemiaMyelofibrosisMyeloproliferative Neoplasm
 
- Interventions
 - Procedure: PBSC Hematopoietic Stem Cell Transplantation (HSCT)Other: Patient Reported OutcomesRadiation: Total-body irradiation
 
- First Posted Date
 - 2023-08-21
 
- Last Posted Date
 - 2025-05-29
 
- Target Recruit Count
 - 313
 
- Registration Number
 - NCT06001385
 
- Locations
 - 🇺🇸
Mayo Clinic Arizona, Phoenix, Arizona, United States
🇺🇸Honor Health, Scottsdale, Arizona, United States
🇺🇸University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States
 
Molecular Evaluation of AML Patients After Stem Cell Transplant to Understand Relapse Events
- Conditions
 - Acute Myeloid Leukemia in Remission
 
- First Posted Date
 - 2022-02-04
 
- Last Posted Date
 - 2025-04-25
 
- Target Recruit Count
 - 303
 
- Registration Number
 - NCT05224661
 
- Locations
 - 🇺🇸
City of Hope, Duarte, California, United States
🇺🇸University of California, San Francisco, San Francisco, California, United States
🇺🇸Stanford University, Stanford, California, United States
 
Protocol for a Research Sample Repository for Hematopoietic Cell Transplantation, Other Cellular Therapies and Marrow Toxic Injuries
- Conditions
 - Marrow Toxic InjuryCellular TherapyAllogeneic Stem Cell TransplantationAutologous Stem Cell Transplantation
 
- First Posted Date
 - 2021-06-09
 
- Last Posted Date
 - 2023-05-03
 
- Target Recruit Count
 - 99999999
 
- Registration Number
 - NCT04920474
 
- Locations
 - 🇺🇸
NMDP Biorepository, New Brighton, Minnesota, United States
 
HLA-Mismatched Unrelated Donor Hematopoietic Cell Transplantation With Post-Transplantation Cyclophosphamide
- Conditions
 - Chronic Myelogenous LeukemiaMixed Phenotype Acute LeukemiaAcute LeukemiaAcute Lymphoblastic LeukemiaChronic Lymphocytic LeukemiaAcute Myelogenous LeukemiaMyelodysplastic SyndromesLymphoma
 
- Interventions
 - Radiation: Total-body irradiationProcedure: PBSC Hematopoietic Stem Cell Transplantation (HSCT)Procedure: Bone Marrow Hematopoietic Stem Cell TransplantationOther: Patient-Reported Outcomes
 
- First Posted Date
 - 2021-05-27
 
- Last Posted Date
 - 2025-07-29
 
- Target Recruit Count
 - 300
 
- Registration Number
 - NCT04904588
 
- Locations
 - 🇺🇸
City of Hope National Medical Center, Duarte, California, United States
🇺🇸University of California San Francisco, San Francisco, California, United States
🇺🇸Stanford University, Stanford, California, United States
 
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News
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Real-World Data Shows Yescarta CAR-T Therapy Safe and Effective in Outpatient Setting
Kite presented real-world data from 238 patients showing comparable safety and effectiveness outcomes for Yescarta CAR-T therapy administered in outpatient versus inpatient settings for relapsed/refractory large B-cell lymphoma.
Experts Call for Ecosystem-Wide Approach to Address Disparities in Stem Cell Therapy Access
Leading experts at the 2025 Transplant and Cellular Therapy Meetings emphasize the critical need to address social vulnerabilities affecting patient access to stem cell transplants and CAR T-cell therapies.
ACCESS Trial Shows Promising Survival Rates with PTCy GVHD Prophylaxis in HLA-Mismatched Transplants
Phase 2 ACCESS trial demonstrates 84% one-year overall survival rate using post-transplant cyclophosphamide for GVHD prevention in HLA-mismatched unrelated donor transplants.
Dana-Farber Researchers to Present Groundbreaking Cellular Therapy Studies at 2025 Tandem Meetings
Dana-Farber researchers will showcase novel findings on multiple myeloma treatment outcomes based on Duffy genotype at the 2025 Tandem Meetings, revealing significant implications for personalized therapy selection.
Narsoplimab Shows Promising Real-World Outcomes in TA-TMA Patients at 2025 Tandem Meetings
Omeros Corporation will present real-world data from 128 transplant patients treated with narsoplimab for TA-TMA under an expanded access program at the 2025 Tandem Meetings in Honolulu.
Social Determinants Drive Disparities in Pediatric Stem Cell Transplant Outcomes and Access
Children from high-poverty neighborhoods face 25% transplant-related mortality compared to 20% in low-poverty areas, with Black children experiencing 65% higher risk of transplant-related mortality.
