Protocol for a Research Sample Repository for Hematopoietic Cell Transplantation, Other Cellular Therapies and Marrow Toxic Injuries

Recruiting

• Conditions: Marrow Toxic Injury; Cellular Therapy; Allogeneic Stem Cell Transplantation; Autologous Stem Cell Transplantation

• Registration Number: NCT04920474
• Lead Sponsor: Center for International Blood and Marrow Transplant Research

Brief Summary

The primary purpose of the Research Sample Repository is to make blood samples available for research studies related to histocompatibility and hematopoietic cell transplantation (HCT) or other cellular therapy.

Representatives of participating centers and investigators or research groups may request access to research samples contained in the Research Sample Repository for the purpose of conducting research including:

* investigating molecular explanations for histocompatibility or clinical outcomes through analysis of genomic, epigenetic, or other biomolecular data

* evaluating the factors that affect transplant or cellular therapy outcome

* studying the distribution of HLA tissue types in different populations

* studying the success of transplantation, cellular therapies or supportive care in the management of marrow toxic injuries

* performing de-linked (anonymous) research

Detailed Description

Research samples will be accepted from the following four categories:

* Hematopoietic Cell or other Cellular Therapy Donors

* Cord Blood Units

* Hematopoietic Cell Transplantation or other Cellular Therapy Recipients

* Patients with Marrow Toxic Injury

Study Timeline

• Study Start: 1991-07
• Study First Submitted: 2021-06-03
• Study First Submitted QC: 2021-06-03
• Study First Posted: 2021-06-09
• Status Verified: 2023-03
• Last Update Submitted: 2023-05-01
• Last Update Posted: 2023-05-03
• Primary Completion: 2030-07
• Study Completion: 2030-07

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 99999999

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To make blood samples available for research studies related to histocompatibility and HCT or other cellular therapy	pre-HCT (recipient) or pre-donation (donor)

Trial Locations

Locations (1)

NMDP Biorepository; 🇺🇸 New Brighton, Minnesota, United States