The Impact of the Timing of Trigger on IVF Success

Not Applicable

Terminated

• Conditions: Infertility; Embryonic Development; Fertilization in Vitro
• Interventions: Other: Timing of trigger

• Registration Number: NCT02990949
• Lead Sponsor: Colorado Center for Reproductive Medicine

Brief Summary

The aim of this study is to examine the length of ovarian stimulation with the timing of trigger in an IVF cycle and its potential to impact patient outcomes.

Detailed Description

Not available

Study Timeline

• Study Start: 2016-11
• Study First Submitted: 2016-12-06
• Study First Submitted QC: 2016-12-09
• Study First Posted: 2016-12-13
• Primary Completion: 2022-05-09
• Study Completion: 2022-06-15
• Status Verified: 2022-10
• Last Update Submitted: 2022-10-12
• Last Update Posted: 2022-10-14

Recruitment & Eligibility

• Status: TERMINATED
• Sex: Female
• Target Recruitment: 29

Inclusion Criteria

• Planning to move forward with an IVF cycle
• Have met the requirements of being a patient at CCRM Colorado
• AMA: 39-44 years old And/or
• DOR: AMH < 1 & FSH >10 (age independent)

Exclusion Criteria

• Contraindication for pregnancy
• Have not fulfilled requirements for IVF cycle
• Single gene couple or chromosomal rearrangement
• Severe male factor or testicular surgical sperm removal (need sufficient sperm for ICSI)
• One ovary
• Uterine anomalies
• Stage III or IV endometriosis
• Explained recurrent miscarriage
• PCO or PCOS
• Using donor oocyte or gestational carrier

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Testing group	Timing of trigger	Timing of trigger at end of ovarian stimulation in an IVF cycle: trigger when 2 follicles reach 18mm, OR 1 follicle reaches 18mm AND 1 follicle is between 16-18mm.

Primary Outcome Measures

Name	Time	Method
Euploid Embryos: the percentage of euploid embryos produced as analyzed by comprehensive chromosomal screening, of total embryos tested	4 weeks after egg retrieval

Secondary Outcome Measures

Name	Time	Method
Live birth outcomes: the incidence of pregnancy resulting in live birth following embryo transfer of embryos produced by this IVF cycle	9 months after frozen embryo transfer
Egg maturation: the proportion of mature eggs of total number of eggs retrieved	1 week after egg retrieval

Trial Locations

Locations (1)

Colorado Center for Reproductive Medicine; 🇺🇸 Lone Tree, Colorado, United States