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Clinical Trials/NCT02990949
NCT02990949TerminatedNot Applicable

The Impact of the Timing of Trigger on IVF Success: Randomized Control Trial

Colorado Center for Reproductive Medicine1 site in 1 country29 target enrollmentStarted: November 1, 2016Last updated:
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Conditions
Interventions

Trial Snapshot

Phase
Not Applicable
Status
Terminated
Enrollment
29
Locations
1
Primary Endpoint
Euploid Embryos: the percentage of euploid embryos produced as analyzed by comprehensive chromosomal screening, of total embryos tested
Study OverviewStudy DesignEligibility CriteriaArms & InterventionsOutcomesInvestigatorsSitesRecords & IdentifiersSimilar Trials

Study Overview

Brief Summary

The aim of this study is to examine the length of ovarian stimulation with the timing of trigger in an IVF cycle and its potential to impact patient outcomes.

Study Design

Study Type
Interventional
Allocation
Randomized
Intervention Model
Parallel
Primary Purpose
Treatment
Masking
None

Eligibility Criteria

Ages
26 Years to 44 Years (Adult)
Sex
Female
Accepts Healthy Volunteers
Yes

Inclusion Criteria

  • •Planning to move forward with an IVF cycle
  • •Have met the requirements of being a patient at CCRM Colorado
  • •AMA: 39-44 years old And/or
  • •DOR: AMH < 1 & FSH >10 (age independent)

Exclusion Criteria

  • •Contraindication for pregnancy
  • •Have not fulfilled requirements for IVF cycle
  • •Single gene couple or chromosomal rearrangement
  • •Severe male factor or testicular surgical sperm removal (need sufficient sperm for ICSI)
  • •One ovary
  • •Uterine anomalies
  • •Stage III or IV endometriosis
  • •Explained recurrent miscarriage
  • •PCO or PCOS
  • •Using donor oocyte or gestational carrier

Arms & Interventions

Testing group

Experimental

Timing of trigger at end of ovarian stimulation in an IVF cycle: trigger when 2 follicles reach 18mm, OR 1 follicle reaches 18mm AND 1 follicle is between 16-18mm.

Intervention: Timing of trigger (Other)

Control group

No Intervention

Outcomes

Primary Outcomes

Euploid Embryos: the percentage of euploid embryos produced as analyzed by comprehensive chromosomal screening, of total embryos tested

Time Frame: 4 weeks after egg retrieval

Secondary Outcomes

  • Live birth outcomes: the incidence of pregnancy resulting in live birth following embryo transfer of embryos produced by this IVF cycle(9 months after frozen embryo transfer)
  • Egg maturation: the proportion of mature eggs of total number of eggs retrieved(1 week after egg retrieval)

Investigators

Sponsor Class
Other
Responsible Party
Sponsor

Study Sites (1)

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