Effect of L-Carnitine on transplanted liver functio
- Conditions
- iver transplantation.Complications of transplanted organs and tissue
- Registration Number
- IRCT20100111003043N12
- Lead Sponsor
- Tehran University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 80
All patients over 14 years old with liver cirrhosis who are candidate for the first liver transplantation on the liver transplant list of Imam Khomeini Hospital Complex
Patient's consent to enter the study
Children under the age of 14 years who are candidate for liver transplantation
Patients candidate for liver re-transplantation
Patients who are candidate for liver transplant due to acute liver failure
Patients undergoing simultaneous multiple organ transplantations (simultaneous liver-kidney transplantation, simultaneous liver-pancreas-kidney transplantation)
Patients undergoing split liver transplantation from living donors or deceased donors
Pregnant or lactating women
History of allergy to L-Carnitine
Patients with a history of seizure
Patients with postoperative unstable conditions such as fever, sepsis, and shock, Cardiac instability (ACS/MI), gastrointestinal bleeding, long-term need for vasopressor (norepinephrine at doses greater than 0.5 µg/kg/min)
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Evaluation of the occurrence of primary graft non-function after liver transplantation. Timepoint: Daily within first week after liver transplantation. Method of measurement: Laboratory evaluation of liver function tests including international normalized ratio, serum aminotransferases, serum bilirubin, lactate concentration, blood glucose, venous or arterial blood pH.;Evaluation of the occurrence of initial graft poor function after liver transplantation. Timepoint: Daily within first week after liver transplantation. Method of measurement: Laboratory evaluation of liver function tests including international normalized ratio, serum aminotransferases, serum bilirubin, lactate concentration, blood glucose, venous or arterial blood pH.
- Secondary Outcome Measures
Name Time Method Evaluation of occurrence of kidney function after liver transplantation. Timepoint: Daily within first week after liver transplantation. Method of measurement: Urinary output measurement and laboratory assessment of serum creatinine concentration.;Evaluating length of ICU stay. Timepoint: Daily from ICU admission to ICU discharge. Method of measurement: Counting the days of ICU stay.;Evaluating length of hospital stay. Timepoint: Daily from transplant surgery to hospital discharge. Method of measurement: Counting the days of hospital stay.