The Perspective of Healthy Individuals on Breast Cancer Risk Prediction Report In The Indonesian Population

Not Applicable

Completed

• Conditions: Breast Cancer
• Interventions: Other: Focus Group Discussion

• Registration Number: NCT05562440
• Lead Sponsor: Nalagenetics Pte Ltd

Brief Summary

In 2016, a meta-analysis showed that DNA-based risk reporting alone does not facilitate behavior change. However, there have been several studies showing that tailoring care plans related to diet may help with adherence to a tailored diet plan.

Risk prediction report displays both Polygenic Risk Score (PRS) and modifiable (non-genetic) risk factors. Overtime, the investigators aim to combine both PRS and modifiable risk factors to have a localized and stronger prediction model for the local population. The risk prediction report is designed to tailor care plans for patients by their physicians or care planner.

Focus groups allow deeper discussions in themes important to guide design of the report. This method has been used in previous similar studies, such as one by Cutting et al to understand physicians' preference in integrating genetic reports into daily practice. Studies also have shown that local adoption of personalized medicine and care is hindered by limited infrastructure of information management and awareness, despite personalized medicine being widely adopted in healthcare systems in developing countries.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2022-09-23
• Study First Submitted QC: 2022-09-28
• Study First Posted: 2022-09-30
• Study Start: 2022-11-08
• Primary Completion: 2023-02-12
• Study Completion: 2023-02-12
• Status Verified: 2023-11
• Last Update Submitted: 2023-11-10
• Last Update Posted: 2023-11-13

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 10

Inclusion Criteria

1. Female
2. Able to give informed consent
3. Aged 25-75 years old
4. Have access to a mobile phone or computer with the Zoom application or a caregiver who is able to assist them with the Zoom application

Exclusion Criteria

1. Ever diagnosed with breast cancer

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Focus Group Discussion on breast cancer risk prediction report	Focus Group Discussion	Woman population with no breast cancer who received the dummy report result

Primary Outcome Measures

Name	Time	Method
Focus Group Discussions	Immediately after exposure to dummy report	To qualitatively investigate participants' perceptions and gather their feedbacks on the clarity, completeness, and their impressions towards the breast cancer risk prediction dummy report. FGD will be transcribed and analyzed using thematic analysis method.

Trial Locations

Locations (1)

MRCCC Siloam Hospitals Semanggi; 🇮🇩 Jakarta, DKI Jakarta, Indonesia