Comparative Evaluation of Clinical and Radiographic Treatment Outcomes of Garlic Gel and Calcium Hydroxide as an Intracanal Medicament in Nonsurgical Root Canal Treatment of Permanent Teeth: A Randomized Controlled Trial.
试验速览
- 阶段
- 3 期
- 状态
- 尚未招募
- 入组人数
- 96
- 主要终点
- CLINICAL AND RADIOGRAPHIC OUTCOMES
研究概览
简要总结
Researchers want to check how well garlic works inside permanent teeth as a medicament during root canal treatments. Garlic has shown to possess many helpful properties, like reducing inflammation, helping wounds heal, and antimicrobial characteristics. Because conventional medicaments can be expensive or have potential side effects, researchers are actively exploring natural options like garlic. Some lab studies have already shown that garlic gel can kill the microbes inside the teeth. However, no real-life clinical or X-ray studies have been done on using garlic in permanent teeth. This study may help scientists find a much safer and effective new material for dental treatments in the future.
详细描述
Clinical trials are needed to evaluate the effectiveness of Allium sativum as an intracanal medicament due to its various useful properties, such as anti-inflammatory, wound healing action, and antimicrobial properties. To overcome the problems with synthetic medicament, researchers are looking for natural alternatives due to their low cost, easy availability, and safety. The objective of the study is to evaluate and compare the clinical and radiographic treatment outcomes of using garlic gel and calcium hydroxide paste as an intracanal medicament in nonsurgical root canal treatment of permanent teeth in terms of:
- Pain.
- Tenderness to palpation.
- Tenderness to percussion.
- Size of Periapical radiolucency.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 15 Years 至 45 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Patients with the physical status of ASA I and ASA II according to ASA classification.
- •Patients aged from 15-45 years.
- •Mature permanent single-rooted teeth with closed apices.
- •Patients with clinical signs of symptomatic apical periodontitis (pain, tenderness to palpation, and percussion).
- •Patients having radiographic evidence of periapical radiolucency of endodontic origin.
- •Patients who have not taken antibiotics for the past 14 days.
- •Cooperative patients who show good compliance.
排除标准
- •Patients with physical status of ASA III, IV, and V according to ASA classification.
- •Teeth with a calcified pulp chamber in periapical radiography.
- •Patients who have undergone previous endodontic treatment failure and those with the presence of sinus tract on clinical examination.
- •Teeth having advanced periodontal disease, with the basic periodontal examination (BPE) of 3 and
- •Presence of internal and external resorption of the root as viewed on the periapical radiograph.
- •Presence of vertical root fracture and perforation as viewed on the periapical radiograph
研究组 & 干预措施
Experimental group(n=48)
Garlic gel will be used as an intracanal medicament
干预措施: Allium Sativum as an intracanal medicament (Drug)
Control group(n=48)
Patients will receive informed consent, clinical exam, and preoperative radiographs. After anesthesia and rubber dam isolation, access, cleaning, and shaping of canals will be performed using standard endodontic techniques. Calcium hydroxide (control) will be placed as intracanal medicament, followed by temporary restoration of Cavit and Glass Ionomer cement. After 14 days, if clinical symptoms of pain, tenderness to palpation and percussion resolve, the medicament will be removed, and the canal will be obturated and permanently restored. However, if the patient remains clinically symptomatic, then another dressing of calcium hydroxide will be placed. Finally, clinical outcomes will be recorded after a month and obturation will be delayed until the complete resolution of clinical signs and symptoms. Patients will return after 6 months for clinical and radiographic evaluation, with pre- and postoperative radiographs compared by two endodontists.
干预措施: Allium Sativum as an intracanal medicament (Drug)
结局指标
主要结局
CLINICAL AND RADIOGRAPHIC OUTCOMES
时间窗: Time frame for clinical outcomes: Baseline to 2 weeks Time frame for radiographic outcomes: Baseline to 6 months
Clinical success will be based on the absence of the following clinical signs and symptoms: Pain Tenderness to palpation of adjacent soft tissues Tenderness to percussion of involved tooth Radiographic outcomes will be measured in terms of size of Periapical radiolucency. The Periapical status will be assessed using the periapical index (PAI) scoring system by Orstavik. Each tooth will be assigned one of the Periapical index scores for 5 categories within the scale. SCORE POSSIBLE OUTCOME 1. Normal periapical structure 2. Small changes in bone structures 3. Change in bone structure with mineral loss 4. Periodontitis with well-defined radiolucency 5. Severe periodontitis with exacerbating features Periapical radiolucency will be classified as resolved if the Periapical index score is less than or equal to score of 2.
次要结局
未报告次要终点
研究者
Zara Rizwan
Principal investigator, MDS Resident
University of Health Sciences Lahore