europhysiological analysis of developmentaldisorders: an exploratory neuroimaging study using functional near-infrared spectroscopy (fNIRS)

Not Applicable

Recruiting

• Conditions: Attention deficit hyperactivity disorder

• Registration Number: JPRN-UMIN000006277
• Lead Sponsor: Department of Neurosurgery, Jichi Medical University Hospital

Brief Summary

There was no significant activation in the lateral prefrontal cortices examined before MPH intake. However, after MPH intake, significant MPH-elicited activation (oxygenated hemoglobin signal increase) was detected in the right lateral prefrontal cortex (LPFC) implicated with response inhibition functions. There was a large significant correlation between increases in task performance and activation in the right LPFC.

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2011-09-05
• Study Completion: 2012-12-01
• Last Update Posted: 17 October 2023

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 15

Inclusion Criteria

Not provided

Exclusion Criteria

(1) Subjects who are diagnosed with anxiety disorder (2) Subjects who are diagnosed with glaucoma (3) Subjects who are diagnosed with hyperthyroidism (4) Subjects who have angina, arrhythmia (5) Subjects who have allergies to MPH (6) Subjects who are diagnosed with tics or Tourette's syndrome, or have family history of Tourette's syndrome (7) Subjects who are diagnosed with severe depression (8) Subjects who are diagnosed with pheochromocytoma (9) Subjects who current or past use of monoamine oxidase inhibitor (MAOI)

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
(1) fNIRS analysis Comparison of frontal activation (oxy-Hb, deoxy-Hb and total-Hb, measured by fNIRS) before and after an acute clinical dose of MPH or placebo (90 min after MPH administration) (2) Behavioral performance Comparison of reaction time and percentage of correct response on Go/NoGo task before and after the acute clinical dose of MPH or placebo (90 min after MPH administration)

Secondary Outcome Measures

Name	Time	Method
The response of continuous administration of MPH on ADHD rating scale and Questionnaire-Children with Difficulties