The Effect of granulocyte colony-stimulating factor and erythropoietin on survival in patients with Acute-on-Chronic Liver Failure.
Phase 4
- Conditions
- Acute-on-Chronic Liver Failure.
- Registration Number
- SLCTR/2018/015
- Lead Sponsor
- Dr. Md. Nazmul Haque
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow up complete
- Sex
- Not specified
- Target Recruitment
- Not specified
Inclusion Criteria
• Age:>18 years
• Sex: both sexes
• Bilirubin > 5 mg/dl
• Coagulopathy (international normalized ratio > 1.5)
• Complicated by clinical ascites and/or encephalopathy within 4 weeks
• Patient with previously diagnosed or undiagnosed chronic liver disease
• Acute insult caused by reactivation of HBV, HBV Flare, HEV,HAV or any aetiology
Exclusion Criteria
• Age <18 years
• Decompensated Cirrhosis
• Coexistent hepatocellular carcinoma (HCC)
• Patients on immune-modulator or cytotoxic/immunosuppressive therapy
• Co morbidity like heart failure, any malignancy and uncontrolled diabetic patients
.
• Any previous known hypersensitivity to G-CSF and EPO
• Patients unwilling to take part in the study
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Change in MELD score (Model for end stage liver disease) [At baseline and 90 days<br><br>]<br>Change in CTP (Child-Turcotte-Pugh) score [ At baseline and 90 days]<br> Survival [ At 90 days]<br>
- Secondary Outcome Measures
Name Time Method one [None]<br>