Study the effect of Granulocyte colony stimulating factor (G-CSF) influence on neurological and cardiac toxicity caused by carbon monoxide in patients with carbon monoxide poisoning

Phase 1

Recruiting

• Conditions: Carbon monoxide poisoning.; Toxic effect of carbon monoxide

• Registration Number: IRCT201607232083N7
• Lead Sponsor: Management and technology assistance of Mashhad university of medical sciences, school of pharmac

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 22 February 2018

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

diagnosis of carbon monoxide poisoning based on clinical and laboratory findings; poisoning severity of moderate to severe based on the concentration of carboxyhemoglobin and clinical symptoms (NIHSS); poisoned patients must be enrolled within 24 hours of incidence of toxicity; Age between 18 and 70 years
Exclusion criteria: Pregnancy; Other Simultaneous poisoning; Burn; the history of neurosurgical and head trauma During the past 4 weeks; multiple trauma 6 - ischemic stroke or hemorrhagic during the last 4 weeks; Malignancies; chronic inflammatory diseases; hematologic malignancies; allergies and or elevated titers of antibodies against erythropoietin and high blood pressure180/110; cardiovascular disease; any previous cerebrovascular lesions

Exclusion Criteria

Not provided

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
S100B serum concentration. Timepoint: Day 1 pre-intervention, 3 and 30 after intervention. Method of measurement: Elysa kit.;NIHSS. Timepoint: Day 1 pre-intervention, 3 and 30 after intervention. Method of measurement: NIHSS scor chart.;Barthel Index. Timepoint: Day 30 after intervention. Method of measurement: Barthel Index chart.;TI serum concentration. Timepoint: In 3,12, 24, 48 and 72 houers after intervention. Method of measurement: Elysa kit.;Cardiac arrhythmias. Timepoint: During 24 h after intervention. Method of measurement: ECG holter monitor.