Effects of Aerobic Exercise Intensity on Affective States and Brain Derived Neurotropic Factor in Patients With Depression
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Depressive Disorder
- Sponsor
- St. Olavs Hospital
- Enrollment
- 21
- Locations
- 1
- Primary Endpoint
- Change in serum brain derived neurotropic factor (BDNF)
- Status
- Completed
- Last Updated
- 7 years ago
Overview
Brief Summary
Acute aerobic exercise improves affective stats in patients with mental illnesses. Brain derived neurotropic factor (BDNF) may be a biological mechanism that contributes to the affective benefits. The magnitude of the increase of serum BDNF might be exercise intensity dependent, but no study has compared low high-aerobic-intensity training at 90-95 % of the maximal heart rate (HRmax) with long-slow-distance training at 70 % of the HRmax in patients with depression.
The aim of this study is to compare changes in serum BDNF levels after high-aerobic-intensity training and long-slow-distance training in a intra-individual design in patients suffering from depression. The results will give indications of a possible difference in BDNF response between aerobic intensities and may be uses as pilot data for calculating sample size.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Moderate or severe depression (ICD10: F32-F33)
Exclusion Criteria
- •Bipolar disorder.
Outcomes
Primary Outcomes
Change in serum brain derived neurotropic factor (BDNF)
Time Frame: 15 minutes before exercise to 5> minutes after exercise.
To measure serum BDNF levels, blood samples will be taken before and after each workout session.
Secondary Outcomes
- Change in affective symptoms(15 minutes before exercise to 15> minutes after exercise.)
- Change in state of anxiety.(15 minutes before exercise and 15> minutes after exercise.)
- Change in subjective exercise experience(15 minutes before exercise to 15> minutes after exercise.)
- Maximal oxygen uptake(Baseline)
- Maximal Heart rate(Baseline)