Brain Derived Neurotropic Factor Response to Aerobic Exercise Intensity in Depressive Patients.

Not Applicable

Completed

• Conditions: Depressive Disorder; Depressive Disorder, Major

• Registration Number: NCT02741622
• Lead Sponsor: St. Olavs Hospital

Brief Summary

Acute aerobic exercise improves affective stats in patients with mental illnesses. Brain derived neurotropic factor (BDNF) may be a biological mechanism that contributes to the affective benefits. The magnitude of the increase of serum BDNF might be exercise intensity dependent, but no study has compared low high-aerobic-intensity training at 90-95 % of the maximal heart rate (HRmax) with long-slow-distance training at 70 % of the HRmax in patients with depression.

The aim of this study is to compare changes in serum BDNF levels after high-aerobic-intensity training and long-slow-distance training in a intra-individual design in patients suffering from depression. The results will give indications of a possible difference in BDNF response between aerobic intensities and may be uses as pilot data for calculating sample size.

Detailed Description

Not available

Study Timeline

• Study Start: 2016-03
• Study First Submitted: 2016-03-15
• Study First Submitted QC: 2016-04-13
• Study First Posted: 2016-04-18
• Primary Completion: 2016-12
• Study Completion: 2016-12
• Status Verified: 2018-12
• Last Update Submitted: 2018-12-03
• Last Update Posted: 2018-12-04

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 21

Inclusion Criteria

• Moderate or severe depression (ICD10: F32-F33)

Exclusion Criteria

• Bipolar disorder.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Primary Outcome Measures

Name	Time	Method
Change in serum brain derived neurotropic factor (BDNF)	15 minutes before exercise to 5> minutes after exercise.	To measure serum BDNF levels, blood samples will be taken before and after each workout session.

Secondary Outcome Measures

Name	Time	Method
Change in affective symptoms	15 minutes before exercise to 15> minutes after exercise.	The positive and negative affect schedule (PANAS) .
Change in state of anxiety.	15 minutes before exercise and 15> minutes after exercise.	A short form of state trait anxiety inventory for adults (STAI) is used to detect their state of anxiety.
Change in subjective exercise experience	15 minutes before exercise to 15> minutes after exercise.	The Subjective exercise experience scale (SEES).
Maximal oxygen uptake	Baseline
Maximal Heart rate	Baseline

Trial Locations

Locations (1)

St.Olavs university Hospital, Departement of Østmarka; 🇳🇴 Trondheim, Norway