Effect of Aerobic Training on Asthmatic Patients

Not Applicable

Completed

• Conditions: Anxiety; Depression; Airway Inflammation
• Interventions: Other: Aerobic training

• Registration Number: NCT00989365
• Lead Sponsor: University of Sao Paulo General Hospital

Brief Summary

The investigators hypothesize that aerobic training can reduce anxiety, depression and airway inflammation and those benefits may be related to changes in autonomic system.

Detailed Description

One-hundred patients with moderate or severe persistent asthma, age ranging from 20 to 50 years-old recruited after a medical consultation. Asthma diagnosis based on GINA1 and patients were under medical treatment for at least 6-months and considered clinically stable (no crises and changes in medication for at least 30 days). Patients diagnosed with cardiovascular, pulmonary or musculoskeletal diseases impairing exercise training were excluded.

Experimental Design: Patients were studied between 2 medical consultation to avoid changes in medication during the study and patients were randomized (by drawing lots) into either Control or Training groups. CG was submitted to a 4-hour educational program and a breathing exercise program and TG was submitted to the same CG procedures plus an aerobic training program individually based on VO2max. Before and after the intervention, patients performed pulmonary function test and cardiopulmonary exercise testing and as well as fulfilled questionnaires to quantify asthma specific HRQL and anxiety and depression levels. Asthma daily symptoms were evaluated monthly.

Study Timeline

• Study Start: 2007-01
• Primary Completion: 2009-09
• Study Completion: 2009-09
• Status Verified: 2009-10
• Study First Submitted: 2009-10-02
• Study First Submitted QC: 2009-10-02
• Last Update Submitted: 2009-10-02
• Study First Posted: 2009-10-05
• Last Update Posted: 2009-10-05

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• 20-50 years old
• moderate and severe asthma

Exclusion Criteria

• other pulmonary or cardiovascular disease

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Patient cousenling	Aerobic training	Improve medicine use Self control asthma crisis Ambient hygiene

Primary Outcome Measures

Name	Time	Method
psychosocial morbidity and airway inflammation	3 months

Secondary Outcome Measures

Name	Time	Method
autonomic modulation, aerobic capacity, pulmonary function	3 months

Trial Locations

Locations (1)

Clinical Hospital, School of Medicine, University of São Paulo; 🇧🇷 São Paulo, Brazil