Knee Aspiration and High Definition MRI for ACL Injury
Not Applicable
Recruiting
- Conditions
- ACL Injury
- Registration Number
- NCT04901858
- Brief Summary
The aim of this pilot study is to understand the biological changes that occur within the knee joint following injury to the anterior cruciate ligament (ACL). This will be achieved through aspiration and analysis of the haemarthrosis which fills the knee following injury. The study will look at inflammatory and healing responses using DNA, RNA and protein analysis.
This, combined with high resolution imaging of the knee and surrounding soft tissue structures, may enable a more patient specific approach to treatment of ACL injury.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 5
Inclusion Criteria
- Diagnosis of ACL injury confirmed by MRI
- All participants must have the capacity to provide informed consent to participate
- Participants must be able to comply with required study visit
Exclusion Criteria
- Participants outside of the specified age range
- Participants who do not have the mental capacity to make informed decisions
- Participants who have meniscal pathology or other injuries requiring urgent surgery
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Primary Outcome Measures
Name Time Method Pattern of injury on High Definition MRI measured by comparison with 3t MRI images Last visit, usually 28 days Outcome will illustrate any additional benefit of high definition MRI
- Secondary Outcome Measures
Name Time Method Identification of acute inflammatory mediators measured by NanoString molecular analysis Last visit, usually 28 days
Trial Locations
- Locations (1)
Cambridge University Hospitals NHS Foundation Trust
🇬🇧Cambridge, United Kingdom