Prospective cohort study to evaluate feasibility and efficacy of systemic chemotherapy followed by carbon-ion radiotherapy for unresectable locally advanced pancreatic cancer
Not Applicable
Recruiting
- Conditions
- nresectable locally-advanced pancreatic cancer
- Registration Number
- JPRN-UMIN000049456
- Lead Sponsor
- Faculty of Medicine, Yamagata University
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 50
Inclusion Criteria
Not provided
Exclusion Criteria
1. No histological or cytological confirmation of malignancy. 2. Resectable (R) or Borderline resectable without arterial abutment (BR-PV). 3. Radiological distant metastases. 4. Age of under 18 or over 79. 5. Performance status is 2 or 3 (ECOG). 6. No measurable disease. 7. Previous treatment with chemotherapy or radiotherapy for pancreatic cancer. 8. Unable to eat orally. 9. Serious comorbidity. 10. Active and ongoing other malignancy. 11. Pregnancy, planing pregnancy or baby. 12. Peripheral neuropathy.
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Disease control rate for 6 months with systemic chemotherapy followed by carbon-ion radiotherapy
- Secondary Outcome Measures
Name Time Method Response rate, Tumor reduction rate, Tumor marker kinetics during the therapy, Overall survival, Progression-free survival, Adverse events, Dose intensity of the agents.