Beta-blockeRs tO patieNts with CHronIc Obstructive puLmonary diseasE (BRONCHIOLE) - BRONCHIOLE-2017

Region Oerebro Laen0 个研究点目标入组 1,700 人开始时间: 2024年6月19日最近更新: 2024年7月22日

适应症

试验速览

暂无简介。

•A diagnosis of COPD confirmed by spirometry showing post bronchodilator value of Forced Expiratory Volume in one second (FEV1)//Forced Vital Capacity (FVC) <70 according to the Global Initiative on Obstructive Pulmonary Disease (GOLD), and with a history of tobacco smoking or occupational/environmental exposure for smoke gas or dust, =40 years of age, Sinus rhythm =50/min and <120 at inclusion, Written informed consent

•Known hypersensitivity to metoprolol or related derivatives, Systolic blood pressure <90 mmHg, Severe bronchial asthma, Current beta-blocker treatment, Inability to provide informed consent, Age below 40 years, Acute on-going exacerbation of COPD, Previous randomization in the BRONCHIOLE trial, Ongoing pregnancy (excluded by pregnancy test in fertile women), AV block II or III unless treated with a pacemaker, Sinus bradycardia (resting heart rate <50/min), Sick sinus syndrome unless treated with a pacemaker, Atrial fibrillation/flutter (AF), Clinical signs of or a previous diagnosis of left-sided heart failure (HF), angina pectoris (AP), myocardial infarction (MI), cerebrovascular disease or critical peripheral ischemia, Systolic blood pressure <90 mmHg, Any tachyarrythmias other than sinus rhythm, Sinustachycardia >120 / min

发起方

Region Oerebro Laen