Beta-blockeRs tO patieNts with CHronIc Obstructive puLmonary diseasE (BRONCHIOLE)
- Conditions
- Chronic obstructive pulmonary diseaseTherapeutic area: Diseases [C] - Respiratory Tract Diseases [C08]
- Registration Number
- CTIS2024-512407-39-00
- Lead Sponsor
- Region Oerebro Laen
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Recruiting
- Sex
- All
- Target Recruitment
- 1700
A diagnosis of COPD confirmed by spirometry showing post bronchodilator value of Forced Expiratory Volume in one second (FEV1)//Forced Vital Capacity (FVC) <70 according to the Global Initiative on Obstructive Pulmonary Disease (GOLD), and with a history of tobacco smoking or occupational/environmental exposure for smoke gas or dust, =40 years of age, Sinus rhythm =50/min and <120 at inclusion, Written informed consent
Known hypersensitivity to metoprolol or related derivatives, Systolic blood pressure <90 mmHg, Severe bronchial asthma, Current beta-blocker treatment, Inability to provide informed consent, Age below 40 years, Acute on-going exacerbation of COPD, Previous randomization in the BRONCHIOLE trial, Ongoing pregnancy (excluded by pregnancy test in fertile women), AV block II or III unless treated with a pacemaker, Sinus bradycardia (resting heart rate <50/min), Sick sinus syndrome unless treated with a pacemaker, Atrial fibrillation/flutter (AF), Clinical signs of or a previous diagnosis of left-sided heart failure (HF), angina pectoris (AP), myocardial infarction (MI), cerebrovascular disease or critical peripheral ischemia, Systolic blood pressure <90 mmHg, Any tachyarrythmias other than sinus rhythm, Sinustachycardia >120 / min
Study & Design
- Study Type
- Interventional clinical trial of medicinal product
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method