Prothrombin Complex Concentrate vs Fresh Frozen Plasma in Goal-directed Bleeding Management in Liver Transplantation Surgery
Phase 4
Not yet recruiting
- Conditions
- Liver Diseases
- Interventions
- Biological: fresh frozen plasmaBiological: prothrombin complex concentrate
- Registration Number
- NCT06144112
- Lead Sponsor
- Konkuk University Medical Center
- Brief Summary
The primary endpoint of this study is the completion time of hemostasis treatment when administered Fresh frozen plasma (FFP) and frozen powder coagulation factor concentrate (PCC) in goal-directed bleeding management for liver transplantation surgery.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- NOT_YET_RECRUITING
- Sex
- All
- Target Recruitment
- 92
Inclusion Criteria
- Liver disease undergoing Liver transplantation
Exclusion Criteria
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description fresh frozen plasma fresh frozen plasma according to the Thromboelastography (TEG) test, CK r-time prolongation, fresh frozen plasma transfusion (FFP) is performed prothrombin complex concentrate prothrombin complex concentrate according to the Thromboelastography (TEG) test, CK r-time prolongation, prothrombin complex concentrate (PCC) is administered
- Primary Outcome Measures
Name Time Method duration from the time diagnosing r-time prolongation to the time achieving bleeding control 1 min
- Secondary Outcome Measures
Name Time Method FFP amount 1 hour FFP transfusion amount during surgery
Platelet amount 1 hour Platelet transfusion amount during surgery
r-time 10 min CK r-time after PCC or FFP
Red Blood Cell amount 1 hour Red Blood Cell transfusion amount during surgery
CRT-MA 10 min CRT-MA after PCC or FFP
oxygenation profile 1 hour PaO2/FiO2 ratio
Bleeding 6 hour Postoperative bleeding amount
CFF-MA 10 min CFF-MA after PCC or FFP