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临床试验/NCT05036265
NCT05036265已完成不适用

Laparoscopic Liver Resection for Colorectal Liver Metastases: Retrospective Analysis of Prognostic Factors and Oncological Outcomes in a Single-center Cohort

General Hospital Groeninge0 个研究点目标入组 200 人开始时间: 2011年9月1日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
发起方
入组人数
200
主要终点
Survival outcomes

研究概览

简要总结

Laparoscopic liver resection (LLR) has gained acceptance as an effective treatment for colorectal liver metastases (CRLM) in selected patients, providing similar oncologic outcomes compared to open liver resection (OLR). A single-center retrospective analysis of a prospectively maintained database was performed. The primary aim of this study was to determine prognostic factors for the survival outcomes associated with LLR for CRLM.

详细描述

LLR was defined as pure LLR, including conversions to OLR. In case of missing data, additional details were retrieved from the individual patient file. Data on patient demographics, timing of diagnosis, neoadjuvant chemotherapy (NAC), tumor characteristics (both primary tumor and CRLM), histopathology, molecular characteristics, operative technique (including classification into anatomically major/technically major/minor LR), intra- and postoperative course, adjuvant chemotherapy (AC) as well as oncological outcomes (OS and DFS) were gathered and analyzed. Postoperative complications were graded according to the Clavien-Dindo classification. Complications were classified as major in case of Clavien-Dindo ≥ 3A.

研究设计

研究类型
Observational
观察模型
Other
时间视角
Retrospective

入排标准

性别
All
接受健康志愿者

入选标准

  • Patients diagnosed with colorectal liver metastases
  • Patients who received laparoscopic liver resection for colorectal liver metastases
  • Patients who received the laparoscopic liver resection between September 2011 and mid-March 2020

排除标准

  • Patients with contraindication for laparoscopic liver resection
  • Refusal to participate in the study

结局指标

主要结局

Survival outcomes

时间窗: 9 years

Overall and disease-free survival (Kaplan-Meier method)

Prognostic factors

时间窗: 9 years

Univariate Cox proportional-hazards regression analysis

次要结局

未报告次要终点

研究者

发起方
General Hospital Groeninge
申办方类型
Other
责任方
Principal Investigator
主要研究者

Dr. M. D'hondt

Dr Mathieu D'Hondt, Principal Investigator

General Hospital Groeninge

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