Laparoscopic Liver Resection for Colorectal Liver Metastases: Retrospective Analysis of Prognostic Factors and Oncological Outcomes in a Single-center Cohort
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 200
- 主要终点
- Survival outcomes
研究概览
简要总结
Laparoscopic liver resection (LLR) has gained acceptance as an effective treatment for colorectal liver metastases (CRLM) in selected patients, providing similar oncologic outcomes compared to open liver resection (OLR). A single-center retrospective analysis of a prospectively maintained database was performed. The primary aim of this study was to determine prognostic factors for the survival outcomes associated with LLR for CRLM.
详细描述
LLR was defined as pure LLR, including conversions to OLR. In case of missing data, additional details were retrieved from the individual patient file. Data on patient demographics, timing of diagnosis, neoadjuvant chemotherapy (NAC), tumor characteristics (both primary tumor and CRLM), histopathology, molecular characteristics, operative technique (including classification into anatomically major/technically major/minor LR), intra- and postoperative course, adjuvant chemotherapy (AC) as well as oncological outcomes (OS and DFS) were gathered and analyzed. Postoperative complications were graded according to the Clavien-Dindo classification. Complications were classified as major in case of Clavien-Dindo ≥ 3A.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Retrospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients diagnosed with colorectal liver metastases
- •Patients who received laparoscopic liver resection for colorectal liver metastases
- •Patients who received the laparoscopic liver resection between September 2011 and mid-March 2020
排除标准
- •Patients with contraindication for laparoscopic liver resection
- •Refusal to participate in the study
结局指标
主要结局
Survival outcomes
时间窗: 9 years
Overall and disease-free survival (Kaplan-Meier method)
Prognostic factors
时间窗: 9 years
Univariate Cox proportional-hazards regression analysis
次要结局
未报告次要终点
研究者
Dr. M. D'hondt
Dr Mathieu D'Hondt, Principal Investigator
General Hospital Groeninge
