owering blood pressure in patients on extracorporeal membrane oxygenation (ECMO) life support

Phase 1

• Conditions: Cardiovascular - Other cardiovascular diseases; Cardiogenic shock

• Registration Number: ACTRN12623000467639
• Lead Sponsor: Sydney Local Health District

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2023-05-05
• Last Update Posted: 15 May 2023

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: All
• Target Recruitment: 11

Inclusion Criteria

Participants will be eligible for this study if all of the following criteria are met:
•Adult (greater than or equal to 18 years old)
•Currently on VA-ECMO or planned to commence VA-ECMO
•Planned to undergo a procedure in the cardiac catheterisation laboratory (eg diagnostic angiography or percutaneous coronary intervention) whilst on VA-ECMO

Exclusion Criteria

Participants will be ineligible for the study if any of the following criteria are met:
•Persons <18 years old
•Patient or next of kin is unable to provide consent
•Patients who have been transferred to the cardiac catheterisation laboratory whilst undergoing extracorporeal cardiopulmonary resuscitation (ECPR)

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Change in left ventricular filling pressure compared to baseline, assessed via direct measurement of LV pressure using a 6Fr pigtail catheter positioned in the LV.[Baseline to completion of nitroprusside infusion.]

Secondary Outcome Measures

Name	Time	Method
Change in left ventricular end-diastolic volume using echocardiography[Baseline to completion of nitroprusside infusion.];Change in aortic velocity-time integral (VTI) using echocardiography[Baseline to completion of nitroprusside infusion];Change in VA-ECMO flow, with reading obtained from the ECMO console[Baseline to completion of nitroprusside infusion]