Comparison of the Effectiveness of Azithromycin and Erythromycin on the rate of clinical chorioamnionitis and Latency period up to termination of pregnancy in women with Preterm Premature Rupture of Membrane pregnancy
Phase 3
Recruiting
- Conditions
- Condition 1: Premature Rupture of Amniotic Membranes. Condition 2: Chorioamnionitis.Preterm premature rupture of membranes, unspecified as to length of time between rupture and onset of laborChorioamnionitis, second trimesterO42.91O41.122
- Registration Number
- IRCT20240513061769N1
- Lead Sponsor
- Zanjan University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Female
- Target Recruitment
- 120
Inclusion Criteria
Gestational age between 26 and 34 weeks
Singleton pregnancy
Confirmed Premature rupture of the water sac
A live fetus
Exclusion Criteria
The presence of any other infection in the mother that requires antibiotic therapy
Fetal congenital anomaly
Delivery within 24 hours after receiving antibiotics
Hypersensitivity to ampicillin, erythromycin, or azithromycin
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Clinical chorioamnionitis. Timepoint: Before the start of the intervention, After the start of the intervention until the time the fetus is completely removed from the uterus. Method of measurement: Fever above 38 degrees Celsius, Fetal Tachycardia, Maternal Tachycardia above 100 beats per minute, Increased WBC Count in the mother's serum to more than 15000 c/mm, or Discharge of purulent fluid from the vagina.
- Secondary Outcome Measures
Name Time Method The period of delay until the childbirth. Timepoint: Every hour until the time of delivery of the fetus. Method of measurement: The elapsed time from the rupture of the water sac to the childbirth of the fetus in hours.