Association Between Severity of Periodontitis and the Level of Anti-citrullinated Protein Antibodies (ACPAs) in Rheumatoid Arthritis Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 62
- 试验地点
- 1
- 主要终点
- Change in the level of anti-citrullinated protein antibodies (ACPAs)
研究概览
简要总结
the relationship between rheumatoid arthritis and periodontal disease is crucial and has been explained via a complex interplay of genetic, environmental, and hormonal factors that influence the host immune tolerance leading to both disease characteristics. The aim of this study is to clinically investigate the correlation between the levels of anti-citrullinated protein antibodies (ACPAs) in gingival crevicular fluid and the severity of periodontal disease and rheumatoid arthritis in rheumatoid arthritis (RA) patients
详细描述
the relationship between rheumatoid arthritis and periodontal disease is crucial and has been explained via a complex interplay of genetic, environmental, and hormonal factors that influence the host immune tolerance leading to both disease characteristics.
The aim of this study is to clinically investigate the correlation between the levels of anti-citrullinated protein antibodies (ACPAs) in gingival crevicular fluid and the severity of periodontal disease and rheumatoid arthritis in rheumatoid arthritis (RA) patients Materials and Methods: a total of 62 participants suffering from periodontitis and rheumatoid arthritis will be referred from the Badr Hospital (Faculty of Medicine, Helwan University) to Misr international university's dental clinic complex. Gingival crevicular fluid (GCF) samples will be collected from the patients . Assessment of ACPAs will be quantified using enzyme-linked immunoassay (ELISA) as the primary outcome Assessment of 2ry outcomes includes clinical periodontal and RA parameters
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Rheumatoid patients fulfilling the ACR criteria for the classification of RA
- •Both genders
- •Presence of at least 8 teeth
排除标准
- •Diabetes Mellitus
- •Pregnant females
- •Patients who had undergone periodontal treatment within last 3 months
- •Antibiotic therapy during last 3 months
- •Other autoimmune diseases
结局指标
主要结局
Change in the level of anti-citrullinated protein antibodies (ACPAs)
时间窗: at baseline and 3 months
assessment of the level of anti-citrullinated protein antibodies (ACPAs) in gingival crevicular fluid
the level of anti-citrullinated protein antibodies (ACPAs)
时间窗: Baseline
assessment of the level of anti-citrullinated protein antibodies (ACPAs) in gingival crevicular fluid
次要结局
- Change in Plaque index (PI)(at baseline and 3 months)
- Change in Probing depth(at baseline and 3 months)
- Change in Clinical attachment Loss(at baseline and 3 months)
- Clinical attachment Loss(Baseline)
- Probing depth(Baseline)