NL-OMON36017
Completed
Not Applicable
Periodontitis and Rheumatoid Arthritis; a link by protein citrullination? A cross-over clinical trial - Periodontitis-RA, cross-over clinical trial
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Not specified
- Sponsor
- niversitair Medisch Centrum Groningen
- Enrollment
- 70
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •RA patients
- •1\. Fulfilling the American College of Rheumatology classification criteria for RA (1987\)
- •2\. Age \> 18 years
- •3\. Fulfilling the classification criteria of periodontal diseases for generalized severe chronic periodontitis according
- •to the 1999 International Workshop for Classification of Periodontal Diseases and Conditions
Exclusion Criteria
- •1\. Infection or inflammation other than periodontitis or RA
- •2 Present malignancy
- •3\. Other conditions which influence the immune system:, diabetes, active thyroid disease, myocardial infarction,
- •stroke or recanalisation of the femoral arteries for claudication \<6 months prior to the study
- •4\. Pregnancy including a 6\-months post\-partem period as well as breastfeeding
- •5\. Malnutrition
- •6\. Alcoholism and drug abuse
- •7\. Pharmacological interference: use of corticosteroids \>10mg/dag, antibiotic use during 3 months prior to the
- •study, allergy to amoxicillin or metronidazole
- •8\. Edentulism
Outcomes
Primary Outcomes
Not specified
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