Periodontitis and Rheumatoid Arthritis; a link by protein citrullination? An observational study.

Completed

• Conditions: gum disease; Periodontal disease; 10003816; 10004018

• Registration Number: NL-OMON36011
• Lead Sponsor: niversitair Medisch Centrum Groningen

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 75

Inclusion Criteria

Study group: RA patients
1. Fulfilling the American College of Rheumatology classification criteria for RA (1987).
2. Age > 18 years.
Control group: individuals without RA, aged >18 years.

Exclusion Criteria

According to the SENIEUR protocol (1984):
1. Infection or inflammation other than periodontitis or RA.
2. Present malignancy.
3. Other conditions which influence the immune system: diabetes, active thyroid disease, myocardial infarction, stroke or recanalisation of the femoral arteries for claudication <6 months prior to the study.
4. Pregnancy including a 6-months post-partem period as well as breastfeeding.
5. Malnutrition.
6. Alcoholism and drug abuse.
7. Pharmacological interference: use of corticosteroids >10mg/dag, antibiotic use during 3 months prior to the study.
8. Edentulism.

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The Dutch Periodontal Screenig Index (DPSI) (van der Velden 2009).</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Disease Activity Score 28 joint count (DAS28)<br /><br>Eastman Interdental Bleeding Index (EIB, Caton&Polson 1985)<br /><br>Visible plaque index (VPI, Ainamo&Bay 1975)<br /><br>ACPA titer<br /><br>Anti-Pg titer<br /><br>Presence of Porphyromonas gingivalis<br /><br>Presence of ACPAs in gingivocrevicular (GCF)<br /><br>Presence of HLA DR/DQ<br /><br>Leucocyte count, ESR, CRP</p><br>