HLA Antibodies in Systemic Lupus Erythematosus

Not yet recruiting

• Conditions: HLA Antibodies; Systemic Lupus Erythematosus

• Registration Number: NCT06921239
• Lead Sponsor: Centre Hospitalier Universitaire, Amiens

Brief Summary

Patients suffering from autoimmune diseases show false-positive results when anti-HLA antibodies are identified. This false positivity makes it difficult to obtain an organ transplant based on immunological compatibility (absence of anti-HLA antibodies directed against graft antigens). The objectives of this project are to study the prevalence of these false positivities in a population of lupus patients, and to evaluate biological tests that can negate these false positivities.

Detailed Description

Not available

Study Timeline

• Status Verified: 2025-03
• Study First Submitted: 2025-03-28
• Study First Submitted QC: 2025-04-08
• Last Update Submitted: 2025-04-08
• Study First Posted: 2025-04-10
• Last Update Posted: 2025-04-10
• Study Start: 2025-05
• Primary Completion: 2025-11
• Study Completion: 2026-05

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• Patients Adults
• Followed in the internal medicine department of Amiens University Hospital - With systemic lupus erythematosus
• Without HLA immunization risk factors (no history of pregnancy, transfusions or transplants)
• With sera stored in the biobank

Exclusion Criteria

• minor Patients
• Opposing the re-use of their personal data for research purposes

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
prevalence of unexplained antibody positivity	6 months	prevalence of unexplained antibody positivity

Trial Locations

Locations (1)

CHRU Amiens; 🇫🇷 Amiens, France