Physical Exercise Versus Rosiglitazone in CAD and Prediabetes
Phase 4
Completed
- Conditions
- Impaired Glucose Tolerance
- Interventions
- Registration Number
- NCT00675740
- Lead Sponsor
- University of Leipzig
- Brief Summary
The aim of this study is to prospectively assess the relative benefits of either treatment with rosiglitazone or physical exercise on endothelial function in patients with impaired fasting glucose or impaired glucose tolerance and coronary artery disease (CAD).
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 45
Inclusion Criteria
- impaired fasting glucose or impaired glucose tolerance
- angiographic evidence of coronary artery disease
Exclusion Criteria
- diabetes mellitus type I or II
- preexisting antidiabetic medication
- unstable angina
- indication for coronary bypass surgery
- significant left main disease
- myocardial infarction within preceding 3 months
- ejection fraction < 40%
- significant heart valve disease
- severe metabolic disorders
- severe disorders in lipoprotein metabolism
- thyroid disorders
- alcohol or drug abuse
- pregnancy
- participation in another trial
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description 2 physical exercise physical exercise 3 control control 1 rosiglitazone -
- Primary Outcome Measures
Name Time Method between-group difference in flow-mediated dilation of the brachial artery 6 months
- Secondary Outcome Measures
Name Time Method relative effects of treatment on parameters of - glucose metabolism - inflammatory plasma markers - markers of endothelial function - cellular markers in muscle and fat biopsies 6 months