Effects of Beef Protein Consumption on Energy Intake

Not Applicable

Completed

• Conditions: Obesity; Severe Overweight
• Interventions: Dietary Supplement: Differences in protein content (En%) of meals

• Registration Number: NCT01646749
• Lead Sponsor: Maastricht University Medical Center

Brief Summary

The purpose of this study is to determine ad libitum daily energy intake, body weight changes and appetite profile in response to protein/carbohydrate and fat ratio over 12 consecutive days, and in relation to age, gender, body mass index (BMI) and fat mass and obesity-associated (FTO) gene alleles.

Detailed Description

The protein leverage hypothesis requires specific evidence whether energy intake would depend on a possible protein intake target in humans. Meat protein as complete protein may show most beneficial effects on variables regarding food intake regulation.

Study Timeline

• Study First Submitted: 2012-07-16
• Study First Submitted QC: 2012-07-18
• Study First Posted: 2012-07-20
• Study Start: 2012-09
• Primary Completion: 2013-02
• Study Completion: 2013-02
• Status Verified: 2013-07
• Last Update Submitted: 2013-07-10
• Last Update Posted: 2013-07-11

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• Healthy
• Age 18-70 years
• BMI 18-35 kg/m2
• Non-smoking
• Weight stable

Exclusion Criteria

• Smoking
• Use of medication
• More than moderate alcohol consumption
• Vegetarian

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Protein intake of 5 energy percent (En%)	Differences in protein content (En%) of meals	-
Protein intake of 15 En%	Differences in protein content (En%) of meals	-
Protein intake of 30 En%	Differences in protein content (En%) of meals	-

Primary Outcome Measures

Name	Time	Method
Body weight change	11 days	Body weight will be measured on day 1, 6 and 12. Subsequently, the change in body weight over time will be calculated.
Appetite profile	12 consecutive days	Appetite profile will be measured by means of questionnaires: visual analogue scales (VAS). Area under the curve (AUC) will be calculated over 12 consecutive days.
Energy intake	12 consecutive days	Total energy intake over 12 days will be determined for each subject by adding energy intake during meals to energy intake from snack consumption.

Trial Locations

Locations (1)

Maastricht University; 🇳🇱 Maastricht, Netherlands