Oxidative Stress and Cardiac Arrest

Completed

• Conditions: Heart Arrest

• Registration Number: NCT00888966
• Lead Sponsor: Institut d'Anesthesiologie des Alpes Maritimes

Brief Summary

Cardiac arrest is a major health problem reaching 375000 cases in Europe each year. Only 5 to 31 % survive after an out of hospital cardiac arrest (OHCA). The main complication after OHCA is the anoxic encephalopathy. Recently mild hypothermia has shown a beneficial effect on survival. But the mechanisms underlying these therapy are not clear.

Cardiac arrest is an example of ischemia reperfusion of the entire body. And it is well demonstrated that reperfusion generates an oxidative stress. But it has never been shown in a clinical setting.

The aim of the study is to evaluate oxidative stress after out of hospital cardiac arrest treated with mild hypothermia.

Detailed Description

Not available

Study Timeline

• Study Start: 2006-04
• Study First Submitted: 2009-04-25
• Study First Submitted QC: 2009-04-25
• Study First Posted: 2009-04-28
• Primary Completion: 2010-06
• Study Completion: 2010-12
• Status Verified: 2011-06
• Last Update Submitted: 2011-06-30
• Last Update Posted: 2011-07-04

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• Out of hospital cardiac arrest

Exclusion Criteria

• refractory shock
• moribund patient
• resuscitation > 60 minutes
• hypothermia < 30 degrees

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Oxidative stress markers and antioxidants after out of hospital cardiac arrest	4 days

Secondary Outcome Measures

Name	Time	Method
Outcome after out of hospital cardiac arrest	6 months
Lactate after out of hospital cardiac arrest	4 days

Trial Locations

Locations (1)

CHU de Nice; 🇫🇷 Nice, France