Evaluation of Oxidative Stress After Out of Hospital Cardiac Arrest Treated With Moderate Hypothermia
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- Oxidative stress markers and antioxidants after out of hospital cardiac arrest
研究概览
简要总结
Cardiac arrest is a major health problem reaching 375000 cases in Europe each year. Only 5 to 31 % survive after an out of hospital cardiac arrest (OHCA). The main complication after OHCA is the anoxic encephalopathy. Recently mild hypothermia has shown a beneficial effect on survival. But the mechanisms underlying these therapy are not clear.
Cardiac arrest is an example of ischemia reperfusion of the entire body. And it is well demonstrated that reperfusion generates an oxidative stress. But it has never been shown in a clinical setting.
The aim of the study is to evaluate oxidative stress after out of hospital cardiac arrest treated with mild hypothermia.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Out of hospital cardiac arrest
排除标准
- •refractory shock
- •moribund patient
- •resuscitation > 60 minutes
- •hypothermia < 30 degrees
结局指标
主要结局
Oxidative stress markers and antioxidants after out of hospital cardiac arrest
时间窗: 4 days
次要结局
- Outcome after out of hospital cardiac arrest(6 months)
- Lactate after out of hospital cardiac arrest(4 days)