Evaluation of Muscle StO2 as a Prognostic Factor After Out of Hospital Cardiac Arrest
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 51
- 试验地点
- 4
- 主要终点
- Reperfusion slope after vascular occlusion test. This parameter will be compared between survivors and non-survivors
研究概览
简要总结
Out of hospital cardiac arrest is a major health problem. Prognosis is still poor even after return to spontaneous circulation. The pathophysiology of cardiac arrest implies ischemia-reperfusion and sepsis like syndrome. These phenomenons can lead to microvascular dysfunction explaining probably multi-organ failure after cardiac arrest. Few means allow the exploration of microvascular function in human. Muscle StO2 is a technique allowing the assessment of microvascular function non-invasively. The aim of this study is to evaluate muscle StO2 as a prognostic factor after out of hospital cardiac arrest.
详细描述
Out of hospital cardiac arrest is a major health problem accounting for 375000 deaths each year in Europe. Even after return to spontaneous circulation, survival is poor because of complications such as post-anoxic encephalopathy and multi-organ failure. The pathophysiology of cardiac arrest implies ischemia-reperfusion and sepsis like syndrome. These conditions are frequently associated with microvascular dysfunction that can be the "motor" of multi-organ failure. Few means allow the exploration of microvascular function in human. Recently, StO2, a non-invasive technique assessing microvascular function has been described. This technique measures the tissular saturation of a muscle using the near-infrared spectroscopy technique. It has been described to be a good prognostic factor during haemorrhagic shock state. Dynamic parameters such as reperfusion slope allow discriminating between survivors and survivors after severe sepsis. This dynamic test assesses the microvasculature recruitment that could be a marker of better prognosis. The aim of this study is to evaluate muscle StO2 as a prognostic factor after out of hospital cardiac arrest.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Out of hospital cardiac arrest
- •Patient aged between 18 and 80 years
- •Having a Social Security System
排除标准
- •Pregnant women, lack of appropriate consent
结局指标
主要结局
Reperfusion slope after vascular occlusion test. This parameter will be compared between survivors and non-survivors
时间窗: Four measurements : on admission, since the body core temperature reaches 34°, after 24 hours of hypothermia and 48 hours after admission to ICU
次要结局
- Muscle StO2 during the first 2 days Lactatemia during the first 2 days These parameters will be compared between survivors and non-survivors(Muscle StO2 will be monitored continuously during the first 2 days Lactatemia will be measured every 12 hours until normalization)
研究者
Department of Clinical Research and Innovation
Department of Clinical Research and innovation (drc)
Centre Hospitalier Universitaire de Nice