NCT04066998Unknown不适用
Cytokine Profile of Conjunctivitis, Performed Through Tears Analysis Among Patients Treated With Dupilumab
适应症
试验速览
- 阶段
- 不适用
- 入组人数
- 15
- 主要终点
- Increase of lacrimal inflammatory cytokines
研究概览
简要总结
This study aims to assess the cytokine profile of tears in patients suffering from conjunctivitis versus patients without ocular involvement, when treated with Dupilumab
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients with severe atopic dermatitis resistant to main immunosuppressive drugs
- •treated with Dupilumab
- •with or without conjunctivitis
- •postmenopausal women (since minimum 24 months), surgically sterilized women or women on contraception
排除标准
- •pregnant or breastfeeding women
结局指标
主要结局
Increase of lacrimal inflammatory cytokines
时间窗: Month 8
Change in inflammatory cytokines in tears collected by capillary before and after treatment with Dupilumab. Analysis will be performed by flow cytometry. Concentrations of the following cytokines wil be measured: interleukin-1 β, interleukin-3, interleukin-4, interleukin-5, interleukin-6, interleukin-8, interleukin-10, interleukin-13, interleukin-17, interferon α, Tumor Necrosis Factor α.
次要结局
- Comparison of the increase of lacrimal inflammatory cytokines between the 2 groups(Month 8)
- Absence/Presence of demodex(Day 0)
- Increase of lacrimal eosinophiles(Month 8)
- Improvement of quality of life(Month 8)
研究者
相似试验
Unknown
不适用
Cytokine Assay in Tears of Healthy Children and With Vernal Keratoconjunctivitis: Case Control Study and Monitoring of Cases at 6 MonthsVernal KeratoconjunctivitisHealthy ChildrenNCT02057822University Hospital, Clermont-Ferrand60
已完成
不适用
Inflammatory Cytokines in Congenital Cataract After Lensectomy and Anterior VitrectomyCongenital CataractNCT04120818yin ying zhao59
已完成
不适用
Efficiency and Changes of Cytokines Expression in Tear After Intense Pulsed Light Treating Dry Eye DiseaseDry Eye SyndromesNCT04165785First Affiliated Hospital of Harbin Medical University64
Unknown
4 期
Cytokine and Visual Outcome Variations in Eyes Receiving RanibizumabAge Related Macular DegenerationDiabetic Macular EdemaMacular EdemaRetinal Vein OcclusionNCT03056092Unity Health Toronto168
Unknown
4 期
Cytokine and Visual Outcome Variations in Eyes Receiving AfliberceptAge Related Macular DegenerationDiabetic Macular EdemaMacular EdemaRetinal Vein OcclusionNCT03056079Unity Health Toronto168