Cytokine Assay in Tears of Healthy Children and With Vernal Keratocunjonctivitis: Case Control Study and Monitoring of Cases at 6 Months
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Concentration of 40 cytokines in tears
研究概览
简要总结
The ocular surface may be the seat of an inflammatory process in many pathology as vernal keratoconjunctivitis. It has been shown that inflammatory cytokines produced by the cells themselves and the constituent cells of the target organ, are the main factors that cause inflammation. The main objective of our study was to compare the concentration of 40 cytokines in vernal keratoconjunctivitis and in control subjects.
详细描述
The ocular surface may be the seat of an inflammatory process in many pathology as vernal keratoconjunctivitis. It has been shown that inflammatory cytokines produced by the cells themselves and the constituent cells of the target organ, are the main factors that cause inflammation. The main objective of our study was to compare the concentration of 40 cytokines in vernal keratoconjunctivitis and in control subjects.
研究设计
- 研究类型
- Observational
- 时间视角
- Prospective
入排标准
- 年龄范围
- 3 Years 至 18 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Childrens between 3 and 18 years
- •Affiliated at system of French social security
- •Signed by the holders of parental authority of the sheet and written consent to participate in this study
- •First consultation at Clermont-Ferrand Hospital for vernal keratocunjunctivitis
排除标准
- •Subject suffering from acute or chronic eye disease in which the physician investigator resound with the results: uveitis, glaucoma, retinopathy
- •Subject who had undergone eye surgery
- •Subject having an infection the day of collection: ENT, digestive, urinary
- •Subject with cancer, mental illness or any other condition in which the physician investigator sound informed consent and / or the results
- •Pregnant subject
- •Subject with contact lenses
- •Subject who judged by the investigating physician not enough cooperating to allow a safe collection
结局指标
主要结局
Concentration of 40 cytokines in tears
时间窗: at time 0
Comparaison of concentration of 40 cytokines in tears between healthy children and children with vernal keratoconjunctivitis
次要结局
- Modification of the inflammatory profile according to the clinical severity and treatment(at 6 month)
- Validation of normal range of cytokines in tears of healthy children(at 6 month)