Cytokine Assay in Tears of Healthy Children and With Vernal Keratocunjonctivitis: Case Control Study and Monitoring of Cases at 6 Months
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Vernal Keratoconjunctivitis
- Sponsor
- University Hospital, Clermont-Ferrand
- Enrollment
- 60
- Locations
- 1
- Primary Endpoint
- Concentration of 40 cytokines in tears
- Last Updated
- 12 years ago
Overview
Brief Summary
The ocular surface may be the seat of an inflammatory process in many pathology as vernal keratoconjunctivitis. It has been shown that inflammatory cytokines produced by the cells themselves and the constituent cells of the target organ, are the main factors that cause inflammation. The main objective of our study was to compare the concentration of 40 cytokines in vernal keratoconjunctivitis and in control subjects.
Detailed Description
The ocular surface may be the seat of an inflammatory process in many pathology as vernal keratoconjunctivitis. It has been shown that inflammatory cytokines produced by the cells themselves and the constituent cells of the target organ, are the main factors that cause inflammation. The main objective of our study was to compare the concentration of 40 cytokines in vernal keratoconjunctivitis and in control subjects.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Childrens between 3 and 18 years
- •Affiliated at system of French social security
- •Signed by the holders of parental authority of the sheet and written consent to participate in this study
- •First consultation at Clermont-Ferrand Hospital for vernal keratocunjunctivitis
Exclusion Criteria
- •Subject suffering from acute or chronic eye disease in which the physician investigator resound with the results: uveitis, glaucoma, retinopathy
- •Subject who had undergone eye surgery
- •Subject having an infection the day of collection: ENT, digestive, urinary
- •Subject with cancer, mental illness or any other condition in which the physician investigator sound informed consent and / or the results
- •Pregnant subject
- •Subject with contact lenses
- •Subject who judged by the investigating physician not enough cooperating to allow a safe collection
Outcomes
Primary Outcomes
Concentration of 40 cytokines in tears
Time Frame: at time 0
Comparaison of concentration of 40 cytokines in tears between healthy children and children with vernal keratoconjunctivitis
Secondary Outcomes
- Modification of the inflammatory profile according to the clinical severity and treatment(at 6 month)
- Validation of normal range of cytokines in tears of healthy children(at 6 month)