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Clinical Trials/DRKS00014698
DRKS00014698
Not yet recruiting
Not Applicable

Pathophysiology of respiratory muscle stength and its contribution to exercise intolerance in patients with congenital heart disease

Institut für Schlafmedizin und neuromuskuläre Erkrankungen Universitätsklinikum Münster0 sites60 target enrollmentJune 15, 2018
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ConditionsQ21Congenital malformations of cardiac septa

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Q21
Sponsor
Institut für Schlafmedizin und neuromuskuläre Erkrankungen Universitätsklinikum Münster
Enrollment
60
Status
Not yet recruiting
Last Updated
last year
OverviewInvestigatorsEligibility CriteriaOutcomesSimilar Trials

Overview

Brief Summary

No summary available.

Registry
who.int
Start Date
June 15, 2018
End Date
TBD
Last Updated
last year
Study Type
Observational
Sex
All

Investigators

Sponsor
Institut für Schlafmedizin und neuromuskuläre Erkrankungen Universitätsklinikum Münster

Eligibility Criteria

Inclusion Criteria

  • •a. Age \> 18 years (no age limit) (Group 1, 2 and 3\)
  • •b. able to consent (Group 1, 2 and 3\)
  • •c. Diagnosis of congenital heart disease according to the most recent Guidelines of the European Society of Cardiology (ESC); \>12 weeks since the diagnosis of congenital heart disease has been made; no hospitalisation for HF in the last 4 weeks; optimal medical therapy in accordance with the most recent Guidelines of the European Society of Cardiology (ESC) with no change in medication in the last 4 weeks and combination therapy for pulmonary arterial Hypertension due to congenital heart disease; where there was no treatment with combination therapy in PAH patients then the reason must be documented
  • •d. Controls (matched for age and gender) with normal findings on echocardiogram, electrocardiogram and normal levels of natriuretic peptide hormone

Exclusion Criteria

  • •a. Body Mass Index (BMI) \> 35
  • •b. Chronic obstructive pulmonary disease, emphysema
  • •c. Presence of severe neurological comorbidities especially primary myopathy, muscular dystrophy, motor neuron disease, phrenic nerve disease, epilepsy, multiple sclerosis, parkinson’s disease
  • •d.Severe psychiatric disease including dementia
  • •e. Cardiac pacemaker

Outcomes

Primary Outcomes

Not specified

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