Use of tablets of Pregabalin and Clonidine to give safer general anesthesia to patients during gall bladder removal operations.

Phase 3

Not yet recruiting

• Conditions: Calculus of gallbladder with othercholecystitis,

• Registration Number: CTRI/2020/09/027926
• Lead Sponsor: Department Of Anesthesiology and Critical Care JNMCH AMU

Brief Summary

TITLE  oral premedication with pregabalin or clonidine for hemodynamic stability during laryngoscopy and laparoscopic cholecystectomy , a comparitive evaluation

INTRODUCTION laryngoscopy acts as noxious stimuli leading to increase in autonomic response , this pressor response may be life threatening for some patients so many anesthetic agents, analgesics, adjuvants have been used to blunt this response.this study has been designed to compare hemodynamic response to laryngoscopy during laparoscopic cholecystectomy between pregabalin, clonidine and a placebo given as premedication.

HYPOTHESIS it is hypothesised that clonidine when given as premedication shows a better hemodynamic stability in patients as compared to pregabalin whereas pregabalin shows better analgesic and sedative propertives.

Detailed Description

Not available

Study Timeline

• Last Update Posted: 2020-09-17
• Study Start: 2020-09-21

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 90

Inclusion Criteria

• Prior Written informed consent.
• Patients scheduled for Laparoscopic Cholecystectomy.
• Patients with ASA grade 1 and 2.

Exclusion Criteria

• Patient refusal or Unco-operative patients History of chronic pain/ neuropathy.
• Patients with co-existing cardiac disease, asthma, severe renal or hepatic dysfunction.
• Anticipated difficult intubation.
• Hypersensitivity reaction.
• Psychiatric and neurological diseases.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To assess and compare the changes in heart rate, systolic, diastolic and mean systemic arterial blood pressure	Before induction | After intubation1min,5min,10min | After creation of pneumoperitonium at 15min,30min,45min | 10min after release of pneumoperitonium | 10min after extubation

Secondary Outcome Measures

Name	Time	Method
To assess and compare post operative pain.	To assess the intra operative and post operative analgesic requirement.

Trial Locations

Locations (1)

Department Of Anesthesiology and Critical Care , JNMCH, AMU; 🇮🇳 Aligarh, UTTAR PRADESH, India

Department Of Anesthesiology and Critical Care , JNMCH, AMU

🇮🇳Aligarh, UTTAR PRADESH, India

aditya kumar

Principal investigator

9570105618

adi198713@gmail.com