The Effect of Intranasally Administered Nitroglycerin on Hemodynamic Response to Laryngoscopy and Intubation Among Patients Undergoing Coronary Artery Bypass Grafting (CABG) Surgery

Not Applicable

Completed

• Conditions: Coronary Artery Bypass Grafting
• Interventions: Drug: Nitroglycerin (NTG)

• Registration Number: NCT06637956
• Lead Sponsor: Muhammad Aamir Latif

Brief Summary

Numerous preventive medications have been used to lessen the cardiovascular response to laryngoscopy and intubation. Though some advantages have been noted, most of these treatments have not been found to be completely satisfying. However, nitroglycerin is the most widely utilized medicine due to its fast effect, short half-life, and absence of sedative qualities.

Detailed Description

The circulatory system under compromise is less resilient to the effects of general anaesthesia. Inducing anaesthesia is a crucial step for cardiac patients because their impaired circulatory systems are less tolerant to depression. During coronary artery bypass grafting surgery, the primary objective of general anesthesia is to reduce sympathetic response to uncomfortable stimuli, including laryngoscopy, intubation, skin incision, sternal splitting, and spreading. A rise in blood pressure is one of the hemodynamic reactions that is typically associated with tracheal intubation and laryngoscopy. The impact of intra nasally delivered nitroglycerin on blood pressure response to laryngoscopy and intubation in patients having non-cardiac surgery is currently contentious; however, this study focus on coronary artery bypass grafting surgery patients.

Study Timeline

• Study Start: 2024-01-01
• Primary Completion: 2024-06-30
• Study Completion: 2024-06-30
• Status Verified: 2024-10
• Study First Submitted: 2024-10-07
• Study First Submitted QC: 2024-10-09
• Last Update Submitted: 2024-10-09
• Study First Posted: 2024-10-11
• Last Update Posted: 2024-10-11

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 58

Inclusion Criteria

• Both genders
• Patients undergoing coronary artery bypass grafting surgery.
• Patients aged 35-60 years.
• Ejection Fraction between 50-60%.
• American Society of Anesthesiologists Classification 3-4.

Exclusion Criteria

• Known hypersensitivity to nitroglycerin.
• Anticipated difficult airway.
• Emergency surgery.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
NTG	Nitroglycerin (NTG)	Received a mg nitroglycerin intranasally two minutes prior to laryngoscopy and intubation

Primary Outcome Measures

Name	Time	Method
Diastolic blood pressure	5 minutes post intubation	Diastolic blood pressure was measure prior to and after intubation
Mean aterial pressure	5 minutes post intubation	Mean arterial pressure was measured prior to and after intubation
Heart rate	5 minutes post intubation	Heart rate was measure prior to and after intubation
Systolic blood pressure	5 minutes post intubation	Systolic blood pressure was measure prior to and after itubation

Trial Locations

Locations (1)

Department of Anesthesia, Rashid Latif Medical College; 🇵🇰 Lahore, Punjab, Pakistan