The Effect of Intranasally Administered Nitroglycerin on Hemodynamic Response to Laryngoscopy and Intubation Among Patients Undergoing Coronary Artery Bypass Grafting (CABG) Surgery
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 58
- 试验地点
- 1
- 主要终点
- Mean aterial pressure
研究概览
简要总结
Numerous preventive medications have been used to lessen the cardiovascular response to laryngoscopy and intubation. Though some advantages have been noted, most of these treatments have not been found to be completely satisfying. However, nitroglycerin is the most widely utilized medicine due to its fast effect, short half-life, and absence of sedative qualities.
详细描述
The circulatory system under compromise is less resilient to the effects of general anaesthesia. Inducing anaesthesia is a crucial step for cardiac patients because their impaired circulatory systems are less tolerant to depression. During coronary artery bypass grafting surgery, the primary objective of general anesthesia is to reduce sympathetic response to uncomfortable stimuli, including laryngoscopy, intubation, skin incision, sternal splitting, and spreading. A rise in blood pressure is one of the hemodynamic reactions that is typically associated with tracheal intubation and laryngoscopy. The impact of intra nasally delivered nitroglycerin on blood pressure response to laryngoscopy and intubation in patients having non-cardiac surgery is currently contentious; however, this study focus on coronary artery bypass grafting surgery patients.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 35 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Both genders
- •Patients undergoing coronary artery bypass grafting surgery.
- •Patients aged 35-60 years.
- •Ejection Fraction between 50-60%.
- •American Society of Anesthesiologists Classification 3-4.
排除标准
- •Known hypersensitivity to nitroglycerin.
- •Anticipated difficult airway.
- •Emergency surgery.
研究组 & 干预措施
NTG
Received a mg nitroglycerin intranasally two minutes prior to laryngoscopy and intubation
干预措施: Nitroglycerin (NTG) (Drug)
结局指标
主要结局
Mean aterial pressure
时间窗: 5 minutes post intubation
Mean arterial pressure was measured prior to and after intubation
Heart rate
时间窗: 5 minutes post intubation
Heart rate was measure prior to and after intubation
Systolic blood pressure
时间窗: 5 minutes post intubation
Systolic blood pressure was measure prior to and after itubation
Diastolic blood pressure
时间窗: 5 minutes post intubation
Diastolic blood pressure was measure prior to and after intubation
次要结局
未报告次要终点
研究者
Muhammad Aamir Latif
Research Consultant
RESnTEC, Institute of Research