Effects of temporary discontinuation of antihypertensive treatment in older patients with cognitive impairment: a randomised controlled trial. The DANTE Study Leiden, Discontinuation of ANtihypertensive Treatment in the Elderly
Completed
- Conditions
- depressie, apathie, dagelijks functioneren en kwaliteit van levenBlood pressure and cognition1000796310012272
- Registration Number
- NL-OMON37958
- Lead Sponsor
- eids Universitair Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 400
Inclusion Criteria
(1) age >= 75 years,
(2) current antihypertensive treatment with a calcium antagonist, beta-blocker, diuretic, ACE-inhibitor, or angiotensin-II-receptor blocker prescribed by their general practitioner for hypertension,
(3) a last systolic blood pressure as reported in the chart of the general practitioner <= 160 mmHg(4) Mini-Mental State Examination (MMSE) score 21t/m 27.
Exclusion Criteria
A history of myocardial infarction and/or coronary reperfusion procedures (CABG/PCI) < 3 years, stroke, or heart failure requiring antihypertensive medication and/or a clinical diagnosis of dementia.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Primary outcome is the change in the compound cognitive score between baseline<br /><br>and follow-up at 4 months after randomisation.</p><br>
- Secondary Outcome Measures
Name Time Method <p>Secondary outcomes are the changes in the four separate cognitive domains<br /><br>(executive functioning, cognitive speed, immediate memory, and delayed memory);<br /><br>depressive symptoms, apathy, daily functioning, and quality of life between<br /><br>baseline and follow-up, 4 months after randomisation; and change in cerebral<br /><br>perfusion at MRI scan.</p><br>