Effects of discontinuation of levothyroxine treatment in older adults: a self-controlled study.

Recruiting

• Conditions: hypothyroidism; underactive thyroid; 10043739

• Registration Number: NL-OMON52395
• Lead Sponsor: eids Universitair Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 11 June 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 415

Inclusion Criteria

Community dwelling patients and nursing home patients aged 60 and over using
levothyroxine continuously for a minimum of 1 year at a stable dose.

Exclusion Criteria

- Last measurement of TSH (thyroid stimulating hormone) >=10 mU/L during
levothyroxine treatment
- A history of thyroidectomy, radioactive iodine treatment, neck irradiation,
congenital hypothyroidism or secondary hypothyroidism
- Concurrent amiodarone or lithium use
- Concurrent use of liothyronine, thiamazole, carbimazole or propylthiouracil.
- Patients using a dose of more than 150 mcg levothyroxine per day
- Diagnosis of heart failure NYHA grade IV
- Diagnosis of dementia
- Incapacitated adults
- Life-expectancy of less than 6 months
- Participation in ongoing trials of therapeutic interventions
- Persons that plan to move out of the region in which the study is being
conducted in the next months

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The primary outcome is the proportion of participants that withdraw their<br /><br>thyroid medication successfully (defined as normal fT4 levels and TSH levels<br /><br><10 mU/L) at 52 weeks after start of the discontinuation.</p><br>