Early Prediction of Outcomes Following Optic Neuritis: Development and Acceptability of a Prognostic Tool (MS Predictor)

简要总结

主要结局

次要结局

• Visual Acuity (LogMAR)(From the date of first optic neuritis diagnosis until the last available follow-up assessment (up to 15 years).)
• Visual Field Mean Deviation (dB)(From the date of first optic neuritis diagnosis until the last available follow-up assessment (up to 15 years).)
• Colour Vision (Number of Ishihara Plates Correctly Identified)(From the date of first optic neuritis diagnosis until the last available follow-up assessment (up to 15 years).)
• Number of Healthcare Consultations Following Optic Neuritis Diagnosis(12 months)
• Number of Investigations Performed Following Optic Neuritis Diagnosis(12 months)
• Time to Diagnostic Investigations Following Optic Neuritis Diagnosis (Days)(12 months)
• Time to Treatment Following Optic Neuritis Diagnosis (Days)(12 months)
• Number of Treatment Episodes Following Optic Neuritis Diagnosis(12 months)
• Health-Related Quality of Life (EuroQol 5-Dimension 5-Level Questionnaire [EQ-5D-5L])(Measured at baseline recruitment and repeated 3-12 months later)
• Vision-Related Quality of Life (National Eye Institute Visual Function Questionnaire-25 [NEI-VFQ-25])(Baseline and repeated 3-12 months later)
• Optic Neuritis-Related Quality of Life (Semi-Structured Questionnaire)(Measured at baseline recruitment and repeated 3-12 months later)
• Fatigue (Patient-Reported Outcomes Measurement Information System [PROMIS] Fatigue 6a)(Baseline recruitment and repeated once 3-12 months later)
• Depression (Patient-Reported Outcomes Measurement Information System [PROMIS] Depression 4a)(Baseline recruitment and repeated once 3-12 months later)
• Work Productivity Loss (Adapted iMTA Productivity Cost Questionnaire [iPCQ])(Baseline recruitment and repeated once 3-12 months later)
• Healthcare Resource Utilisation: Appointments, Emergency Department Attendances and Hospital Admissions (Adapted iMTA Medical Consumption Questionnaire [iMCQ])(Baseline recruitment and repeated once 3-12 months later)
• Healthcare Resource Utilisation: Investigations and Treatment Interventions (Adapted iMTA Medical Consumption Questionnaire [iMCQ])(Baseline recruitment and repeated once 3-12 months later)
• Informal Care Received (Hours)(Baseline recruitment and repeated once 3-12 months later)
• Out-of-Pocket Costs (Pounds Sterling)(Baseline recruitment and repeated once 3-12 months later)
• Knowledge, Attitudes and Practices/Behaviours Regarding Genetic Risk Prediction (KAP Questionnaire)(Baseline recruitment and repeated at 3-12 months later)