Immune ageing in health and disease - Immune ageing in health and disease

niversitair Medisch Centrum Groningen0 个研究点目标入组 300 人开始时间: 待定最近更新: 2024年4月29日

适应症

试验速览

暂无简介。

•Group 1: Healthy young donors
•1. Having no chronic diseases
•2. Healthy according to SENIEUR protocol
•3. Not-frail according to frailty instruments (Fried)
•4. Age 19-39 years
•5. Being able to give informed consent;Group 2: Healthy intermediate-age donors
•1. Having no chronic diseases
•2. Healthy according to SENIEUR protocol
•3. Not-frail according to frailty instruments (Fried)
•4. Age 40-60 years
•5. Being able to give informed consent;Group 3: Non-frail, SENIEUR elderly donors
•1. Healthy according to SENIEUR protocol
•2. Not-frail according to frailty instruments (Fried, TFI, GFI)
•3. Age >= 60 years
•4. Being able to give informed consent;Group 4: Non-frail, non-SENIEUR elderly donors
•1. Not fully healthy according to SENIEUR protocol
•2. Not-frail according to frailty instruments (Fried, TFI, GFI)
•3. Age >= 60 years
•4. Being able to give informed consent;Group 5: Low-Frail, non-SENIEUR elderly donors
•1. Not fully healthy according to SENIEUR protocol
•2. Low/intermediate frail according to frailty instruments (Fried, TFI, GFI)
•3. Age >= 60 years
•4. Being able to give informed consent;Group 6: High-Frail, non-SENIEUR elderly donors
•1. Not healthy according to SENIEUR protocol
•2. High or fully frail according to frailty instruments (Fried, TFI, GFI)
•3. Age >= 60 years
•4. Being able to give informed consent

•In general:
•1. No informed consent
•2. Clinical signs of severe anaemia, or persons known to have anaemia defined as a hemoglobulin level of less than 6,0 g/dL
•3. Pregnancy;Non-SENIEUR elderly donors
•1. Disease that has been reported to influence the immune system (active infection, inflammatory disease, malignancy, dementia, alcohol or drug abuse)
•2. Drugs that have been reported to influence the immune system (corticosteroids, other immuno suppressive therapy, vaccination in prior 4 weeks)

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