Early Variations in Immune Aging
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 1,000
- 试验地点
- 1
- 主要终点
- Metagenomics
研究概览
简要总结
Background:
Despite an increase in lifespan over the last decades, our healthspan lags behind. In our aging population, it is pressing that we prevent age-related morbidities and associated burden on the health care system. Instead of investigating aging in already aged populations, the currently proposed study aims to elucidate the process of immune aging in relation to biological aging, demographic and lifestyle factors in young and midlife adults, and to identify early biomarkers and pathways associated with fast versus slow immune aging and aging endotypes.
Study design:
A single-center, observational prospective cohort study in the Netherlands. Participants from priorly established cohorts will be invited to join the EVIA-study. We will obtain demographic and basic clinical data and biological samples (blood and stool) at baseline and after three years, with a short, yearly online questionnaire in between.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 20 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Aged between 20 and 60 years;
- •Able to communicate orally in Dutch or English;
- •Able to give informed consent.
排除标准
- •Any systemic disease or condition, or the use of systemic medication, with the exception of the following:
- •Cardiovascular disease and related medication
- •Metabolic syndrome, including diabetes, hypertension, and hyperuricemia
- •Pregnancy at inclusion (will be recorded during study);
- •Acute illness or fever <1 month before inclusion;
- •Received vaccines or antibiotics 3 months before inclusion;
- •Participation in an intervention trial;
- •Legally incapacitated or unwilling to provide informed consent.
结局指标
主要结局
Metagenomics
时间窗: At baseline and after 3 years
From stool microbiome
Clinical events
时间窗: Between baseline and the 3-year timepoint
Hospital admissions and new medical diagnoses
Immunological function
时间窗: At baseline and after 3 years
As comprised by cytokine porudction capacity, immunophenotyping, circulating inflammatory markers and metabolomics
Immunological Aging Score
时间窗: At baseline and after 3 years
As scored by immune population aging scores, an inflammatory aging score (unpiblished work) and a transcriptomics aging score (idem)
Biological Aging Score
时间窗: At baseline and after 3 years
As scored by epigenetic aging (scored by means of DNA methylation), organ aging (Oh et al) and lipidomic aging scores (unpublished)
Genetics and epigenetics
时间窗: At baseline and after 3 years
SNPs, telomere attrition, accessible loci
次要结局
未报告次要终点