Effect of 12-month daily resveratrol supplementation on brain health in post-menopausal women (Supporting healthy ageing in women with resveratrol - RESHAW)

Phase 2

Completed

• Conditions: Alternative and Complementary Medicine - Other alternative and complementary medicine; Neurological - Dementias; Menopause; Musculoskeletal - Osteoporosis

• Registration Number: ACTRN12616000679482
• Lead Sponsor: niversity of Newcastle

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2016-05-25
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: Female
• Target Recruitment: 170

Inclusion Criteria

Women aged 45-85 years old. Post-menopausal (cessation of menses for > 12 months), with no change in medication type or dose for 3 months before the intervention.

Exclusion Criteria

Consuming HRT or seeking alternative therapy for the relief of postmenopausal symptoms (within the past three months).
Pregnant or breastfeeding.
Clinic BP >160mmHg systolic or 100mmHg diastolic (determined at screening).
BMI>40kg/m2 (determined at screening).
Dementia.
History of breast or cervical cancer, mastectomy or hysterectomy (not due to prolapse).
Smokers or currently on nicotine therapy.
Neurological conditions.
Kidney/liver disease.
Insulin therapy.
Warfarin therapy.
Regularly consuming more than four standard alcoholic drinks per day.
Major depression as diagnosed by a health care professional.
Illiterate.
Physical difficulty that will impede motor and locomotive performance.
Unable to walk without assistance from people (walking aids okay).
Unwilling to maintain pre-enrolment physical activity levels and dietary habits for the duration of the trial.
Unwilling to refrain from consuming stimulants before each clinic visit.
Currently consuming resveratrol containing supplements.
Have any other medical condition or treatments (including supplements) which, in the investigators’ opinion, may confound the outcome of the study.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Overall performance of a neuropsychological test battery following resveratrol supplementation: The neuropsychological test battery will consist of Rey Auditory Verbal Learning Test (verbal memory), the Trail Making Task (measure of attentional and executive functions, which becomes impaired with age), the N-back task and the NIH Toolbox Battery of cognitive function.[12 months and 24 months (due to crossover, half the participants will have completed resveratrol supplementation at 12 months and the other half at 24 months)]