Study on the pharmacodynamic interactions between propofol and sevoflurane during induction of anesthesia.
- Conditions
- Anesthesia
- Registration Number
- EUCTR2005-004632-40-BE
- Lead Sponsor
- niversity Hospital Ghent
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Recruiting
- Sex
- All
- Target Recruitment
- 60
American Society of Anesthesia class I and II patients
18-60 years
Scheduled for surgery under general anesthesia
Are the trial subjects under 18? no
Number of subjects for this age range:
F.1.2 Adults (18-64 years) yes
F.1.2.1 Number of subjects for this age range
F.1.3 Elderly (>=65 years) no
F.1.3.1 Number of subjects for this age range
Weight less than 70% or more than 130% of ideal body weight
neurological disorder
diseases involving the cardiovascular system (hypertension, coronary artery disease, prior AMI, any valvular and/or muscular disease involving decrease of the ejection fraction, arrhythmias, which are either symptomatic or require continuous medication/pacemaker/AICD)
pulmonary disease including asthma, severe COPD, ...
Gastric diseases including reflux
Endocrinological diseases
recent use of psycho-active medication, including alcohol
Study & Design
- Study Type
- Interventional clinical trial of medicinal product
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Main Objective: To investigate the pharmacodynamic interaction between propofol and sevoflurane.;Secondary Objective: ;Primary end point(s): Pharmacodynamic clinical effects:<br> * hypnotic (as measured by computerised EEG)<br> * analgesic (movement in response to different clinically relevant noxious stimuli)
- Secondary Outcome Measures
Name Time Method