Confirming the pharmacological interaction between colchicine and 18F-choline PET

Completed

• Conditions: Prostate cancer; 10038597

• Registration Number: NL-OMON38465
• Lead Sponsor: Antoni van Leeuwenhoek Ziekenhuis

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 5

Inclusion Criteria

- Histopathologically proven prostate cancer
- Suspected of disease recurrence because of PSA relapse
- Scheduled for routine FCH-PET for restaging

Exclusion Criteria

- Age < 18 years
- Mentally incompetent
- Pre-existent bone marrow disease (Hb<7.5 mmol/l, L<4.0x109/l, Tr<150x109/l)
- Pre-existent kidney disease (GFR<60 ml/min/1.7)
- Currently on chemotherapy

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The main study parameter is the uptake of FCH, as seen on PET, in the presence<br /><br>and absence of colchicine. The main study endpoint is the presence of an<br /><br>interaction, defined as colchicine induced absence of FCH transport from blood<br /><br>to tissues.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>SUVmean of FCH uptake in various tissues, including e.g. tumor, liver, muscle,<br /><br>bone marrow and blood.</p><br>