Neuromuscular Ultrasonography Utility for Detection of Peripheral Neuropathy in Systemic Lupus Erythematosus

Completed

• Conditions: Peripheral Neuropathy; System; Lupus Erythematosus
• Interventions: Diagnostic Test: neuromuscular ultrasound

• Registration Number: NCT04527172
• Lead Sponsor: Assiut University

Brief Summary

This study aims to evaluate the rule of NMUS in detection of peripheral neuropathy in SLE patient and to correlate it to traditional neurophysiological studies, clinical signs and activity of SLE.

Detailed Description

The frequency of SLE peripheral neuropathy documented by electrophysiology has been estimated to be approximately 30%.

The term peripheral neuropathies include symmetric polyneuropathy, single and multiple mononeuropathy, and radiculopathy.

There has been increasing interest in using ultrasonography (US) to aid peripheral neuropathy diagnosis and studies have shown good correlation with other imaging modalities. US is a non-invasive and inexpensive imaging device that has become widely available as a diagnostic tool at many fields.

so systemic lupus patients were enrolled in the study , performed nerve conduction study and neuromuscular ultrasound for bil. median, ulnar, peroneal, tibial and sural nerves , on statistics the cross sections were compared in neurophusiologically affected and non affected nerves, also the sensitivity and specifity of NMUS in comparison to the traditional NCS was calculated

Study Timeline

• Study Start: 2018-05-20
• Primary Completion: 2019-05-28
• Study Completion: 2020-05-15
• Status Verified: 2020-08
• Study First Submitted: 2020-08-22
• Study First Submitted QC: 2020-08-25
• Study First Posted: 2020-08-26
• Last Update Submitted: 2020-08-26
• Last Update Posted: 2020-08-28

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 55

Inclusion Criteria

1. All adult SLE patients who was admitted to Rheumatology & Rehabilitation department of Assuit university hospital during time frame of study.
2. apparently healthy subjects with normal electrophysiological study
3. verbal consent, free and informed

Exclusion Criteria

• • Other causes of peripheral neuropathy:

  1. Traumatic
  2. Purely degenerative
  3. Diabetic
  4. Toxic
  5. Infections
  6. Drug induced

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
systemic lupus patients	neuromuscular ultrasound	Nerve conduction study and neuromuscular ultrasound for median , ulnar, tibial, peroneal and sural nerves
Healthy subjects	neuromuscular ultrasound	Nerve conduction study and neuromuscular ultrasound for median , ulnar, tibial, peroneal and sural nerves

Primary Outcome Measures

Name	Time	Method
evaluate the rule of NMUS in detection of peripheral neuropathy in SLE patient	6months	Measuring sensitivity and specificity of neuromuscular ultrasound in comparison to nerve conduction study
Describing the patterns of peripheral nerve affection in SLE patient	6months	Evaluating different studied nerves clinically, electrophyiologically and by neuromuscular ultrasonography

Trial Locations

Locations (1)

Assuit university hospital; 🇪🇬 Assiut, Egypt