Dual Task Aerobic Exercise for Older Adults With Cognitive Impairment (HM2)
- Conditions
- Cognitive Impairment
- Registration Number
- NCT01572311
- Lead Sponsor
- Parkwood Hospital, London, Ontario
- Brief Summary
The investigators proposed research will establish whether combining aerobic exercise with cognitive challenges is feasible and effective in community dwelling older adults with early signs of cognitive impairment.
- Detailed Description
To determine the effects of dual-task aerobic exercise training on community dwelling older adults with early signs of cognitive impairment. We will compare an exercise intervention (E-I) versus an exercise control (E-C) group. Each week, both groups will accumulate a minimum of 120 minutes of exercise (target 150 minutes) from community-based group classes (50 minutes of aerobic exercise) and also complete 45 minutes of beginner-level Square Stepping Exercise (SSE). The E-I group will also answer cognitively challenging questions while doing SSE (dual-task training). This study will determine whether a combined multiple modality (primary component being aerobic exercise) and dual-task exercise program is both feasible and effective for improving cognitive and mobility status, as well as vascular compliance, in older adults who may be at risk for cognitive and mobility decline.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 44
- Male/Female 55-90 years old.
- Montreal Cognitive Assessment score ≤27
- Preserved Instrumental Activities of Daily Living (based on Lawton-Brody Instrumental Activities of Daily Living Sale)
- Dementia (i.e., Mini-Mental Examination score <24 or self-reported physician diagnosis)
- Major Depression (>=16 on the Center for Epidemiologic Studies - Depression Scale combined with clinical judgment by primary study physician)
- Other neurological or psychiatric disorders
- Recent history of severe cardiovascular conditions
- Significant orthopedic conditions
- Have blood pressure >180/100 mmHg or <100/60 mmHg
- Unable to comprehend questionnaire material/study procedures
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Global cognitive functioning 26 weeks Four standardized domain-specific composite scores were averaged to create this standardized global cognitive functioning score (incorporates executive function, processing speed, verbal learning and memory, and verbal fluency.
- Secondary Outcome Measures
Name Time Method Step length under single-task conditions 12, 26 and 52 weeks Mean step length measured with GAITRite system
Global cognitive functioning 12 & 52 weeks Four standardized domain-specific composite scores were averaged to create this standardized global cognitive functioning score (incorporates executive function, processing speed, verbal learning and memory, and verbal fluency.
Executive Function/Mental Flexibility 12, 26, and 52 weeks Standardized scores from seconds to complete Trail Making Test Part A and Trail Making Test Part B averaged to create this standardized composite score
Processing Speed 12, 26 and 52 weeks Standardized score from the Digit-Symbol Substitution Test (total correct responses)
Verbal Learning and Memory 12, 26 and 52 weeks Standardized scores from Auditory Verbal Learning Test (number of words learned and number of words recalled) were averaged to create this standardized composite score
Verbal Fluency 12, 26 and 52 weeks Standardized scores from semantic (number of animals) and phonemic (number of words starting with C) were averaged to create this standardized composite score
Gait variability (step length) under dual-task conditions 12, 26 and 52 weeks Gait variability is the stride-to-stride fluctuations of the way someone walks and will be calculated as coefficient of variation of step length (SD/mean x 100). Measured with GAITRite system.
Gait variability (step length) under single-task conditions 12, 26 and 52 weeks Gait variability is the stride-to-stride fluctuations of the way someone walks and will be calculated as coefficient of variation of step length (SD/mean x 100). Measured with GAITRite system.
Gait speed under dual-task conditions 12, 26 and 52 weeks Average walking speed measured with GAITRite system
Gait speed under single-task conditions 12, 26 and 52 weeks Average walking speed measured with GAITRite system
Double support (seconds and % gait cycle time) under dual-task conditions 12, 26 and 52 weeks Initial double support occurs from heel contact of one footfall to toe-off of the opposite footfall. Terminal double support occurs from opposite footfall heel strike to support footfall toe-off.Total double support is the sum of the initial double support added to the terminal double support. It is measured in seconds (sec) and also expressed as a percent of the Gait Cycle time for the same foot. Measured with GAITRite system
Double support (seconds and % gait cycle time) under single-task conditions 12, 26 and 52 weeks Initial double support occurs from heel contact of one footfall to toe-off of the opposite footfall. Terminal double support occurs from opposite footfall heel strike to support footfall toe-off.Total double support is the sum of the initial double support added to the terminal double support. It is measured in seconds (sec) and also expressed as a percent of the Gait Cycle time for the same foot. Measured with GAITRite system
Step length under dual-task conditions 12, 26 and 52 weeks Mean step length measured with GAITRite system
Carotid artery compliance 12, 26 and 52 weeks Measured from non-invasive vascular assessment with B-mode Ultrasound over the carotid artery (in the neck)
Carotid artery Intima-media thickness (IMT) 12, 26 and 52 weeks Measured from non-invasive vascular assessment with B-mode Ultrasound over the carotid artery (in the neck)
Ambulatory systolic blood pressure 12, 26 and 52 weeks Average systolic blood pressure over a 24-hour time frame
Clinic systolic blood pressure 12, 26 and 52 weeks Average systolic blood pressure from final 2 (out of 3) readings
Ambulatory diastolic blood pressure 12, 26 and 52 weeks Average diastolic blood pressure over a 24-hour time frame
Clinic diastolic blood pressure 12, 26 and 52 weeks Average diastolic blood pressure from final 2 (out of 3) readings
Total balance score 12, 26, and 52 weeks Total balance score calculated from the Fullerton Advanced Balance Scale
Total Falls Self-Efficacy score 12, 26, and 52 weeks Total falls self-efficiacy score calculated from the Falls Self-Efficacy International (FES-I) scale
Trial Locations
- Locations (1)
Aging, Rehabilitation and Geriatric Care Research Center
🇨🇦London, Ontario, Canada
Aging, Rehabilitation and Geriatric Care Research Center🇨🇦London, Ontario, Canada