Assessment of Treatment Effect on Brain Changes in Obstructive Sleep Apnea Syndrome Using MRI

Not Applicable

• Conditions: Obstructive Sleep Apnea (OSA).; Obstructive sleep apnea (adult) (pediatric); G47.33

• Registration Number: IRCT20220410054475N1
• Lead Sponsor: Tehran University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 2 May 2022

Recruitment & Eligibility

• Status: Pending
• Sex: All
• Target Recruitment: 12

Inclusion Criteria

Patients who have been diagnosed with obstructive sleep apnea syndrome after a sleep test.

Exclusion Criteria

People who have a background of respiratory disease (other than apnea).
People with a history of malignancy.
People with a history of cardiovascular disease.
People with a history of neurological diseases (such as neurodegenerative diseases, epilepsy and head trauma).
People who abuse alcohol or drugs or take psychotropic drugs while studying.
People who have structural lesions in the brain.
People who, in addition to obstructive sleep apnea, also have hypoventilation syndrome.
People with metabolic diseases (such as polycythemia).
Patients who, after PSG and clinical tests, are diagnosed as not candidates for CPAP treatment.
People who have contraindications to MRI scans (such as people with cardiac pacemakers and metal implants or even people with a fear of closed space (Claustrophobia)).

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Brain Cortical Thickness. Timepoint: Before treatment, 6 months after treatment. Method of measurement: Analysis of structural MR images.;Functional connection of brain areas (rsFC). Timepoint: Before treatment, 6 months after treatment. Method of measurement: Analysis of functional MR images.;Oxygen Extraction Fraction (OEF). Timepoint: Before treatment, 6 months after treatment. Method of measurement: Analysis of structural MR images.