The Relationship Between Blood Glucose and Satiety Ratings

Not Applicable

• Conditions: Satiety; Appetite
• Interventions: Behavioral: satiety ratings; Dietary Supplement: Generation UCAN supplementation; Dietary Supplement: Mirexus PhytoSpherix supplementation

• Registration Number: NCT04183855
• Lead Sponsor: Western University, Canada

Brief Summary

Participants will be given a drink (and no drink for one of the treatments) prior to a pizza dinner. Ratings on satiety, appetite and desire to eat will be asked with the use of a questionnaire. Blood glucose will also be measured. One hour after the drink, participants will be given a pizza and can eat as much as they want. The pizza remaining will be weighed.

Detailed Description

Each participant will receive all three treatments on separate occasions in random order (separated by a week). The three treatments include control (no supplement), carbohydrates - protein (Generation UCAN supplement, 250ml, 10% solution) and carbohydrates alone (Mirexus PhytoSpherix, 250ml, 10% solution). Participants will report to the lab between 4-5 pm and 4 hours after their last meal on day they have not exercised. Participants will record food intake the day of the first experiment and will be asked to replicate both type and quantity for subsequent visits. Upon arrival at the lab, baseline measures (blood glucose as well as rating of satiety ratings, appetite and desire to eat (10-point visual analogue scale). Then the treatment will be given and all the aforementioned variables will be remeasured at 15, 30, 45 and 60 minutes post drink. At 65 minutes, participants will be provided with an ad libitum pizza meal. Participants will be told to eat until they are "comfortably full" (Bellissimo et al., 2008). The pizza provided will be weighed initially and once the participant is done eating and has left the lab, the remaining pizza will be weighed and recorded. The pizza will be a cheese only pizza to minimize any difference in energy intake due to the location of additional items placed on the pizza.

Participants will not be told the true purpose of this experiment, instead they will be told that the pizza meal is a reward for participating in the study. Later, at the conclusion of the study all will be debriefed.

Study Timeline

• Status Verified: 2019-11
• Study First Submitted: 2019-11-26
• Study First Submitted QC: 2019-11-28
• Study First Posted: 2019-12-03
• Last Update Submitted: 2020-01-13
• Last Update Posted: 2020-01-18
• Study Start: 2020-02-01
• Primary Completion: 2020-06-30
• Study Completion: 2020-08-31

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 24

Inclusion Criteria

• Healthy males and females at the age of 18-40
• sedentary individuals

Exclusion Criteria

• exercise more than twice per week
• does not like pizza
• do not eat three meals a day
• medications that affect eating patterns
• have metabolic and gastrointestinal diseases

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
control	satiety ratings	no supplement will be provided on the day of the experiment
Generation UCAN	satiety ratings	carbohydrates - protein (Generation UCAN supplement, 250ml, 10% solution)
Generation UCAN	Generation UCAN supplementation	carbohydrates - protein (Generation UCAN supplement, 250ml, 10% solution)
Mirexus PhytoSpherix	Mirexus PhytoSpherix supplementation	carbohydrates alone (Mirexus PhytoSpherix, 250ml, 10% solution)
Mirexus PhytoSpherix	satiety ratings	carbohydrates alone (Mirexus PhytoSpherix, 250ml, 10% solution)

Primary Outcome Measures

Name	Time	Method
changes in satiety ratings after the drink	15, 30, 45, 60 min after the drink	satiety ratings will be asked with the use a 10 point visual analog scale (VAS) questionnaire, 10 being do not want to consume any more food and 1 being strong desire to consume food
Food intake	90 min after the drink	food intake after each treatment will be measured by weighing the left over pizza slices

Secondary Outcome Measures

Name	Time	Method
changes in appetite ratings after the drink	15, 30, 45, 60 min after the drink	appetite ratings will be asked with the use a 10 point visual analog scale (VAS), 10 being strong desire to consume food and 1 being no desire to consume food at all
changes in blood glucose after the drink	15, 30, 45, 60 min after the drink	blood glucose will be measured through finger pricks
changes in desire to eat ratings	15, 30, 45, 60 min after the drink	desire to eat ratings will be asked with the use a 10 point visual analog scale (VAS), 10 being no desire to eat at all and 1 being strong desire to eat

Trial Locations

Locations (1)

Exercise Nutrition Laboratory (Western University); 🇨🇦 London, Ontario, Canada