Évaluation de l'Impact du Compressed Sensing Sur le Signal QSM

Recruiting

• Conditions: MRI

• Registration Number: NCT04907487
• Lead Sponsor: Fondation Ophtalmologique Adolphe de Rothschild

Brief Summary

Patients who have agreed to participate in the study will complete the MRI protocol as part of routine care, to which a maximum of four additional 25-minute sequences will be added.

MRI of routine care includes at least the following sequences:

* 3D T1 TFE (2 minutes)

* T2 TSE (2 minutes)

* 3D FLAIR (3 minutes)

The sequences added by the research lasting 25 minutes are:

* SWI QSM 1.0iso 8 echoes (10 minutes)

* SWI QSM 1.0iso 8 echoes CS 6 (7 minutes)

* SWI QSM 1.0iso 8 echoes CS 9 (5 minutes)

* SWI QSM 1.0iso 8 echoes CS 12 (3 minutes)

Detailed Description

Patients who have agreed to participate in the study will complete the MRI protocol as part of routine care, to which a maximum of four additional 25-minute sequences will be added.

MRI of routine care includes at least the following sequences:

* 3D T1 TFE (2 minutes)

* T2 TSE (2 minutes)

* 3D FLAIR (3 minutes)

The sequences added by the research lasting 25 minutes are:

* SWI QSM 1.0iso 8 echoes (10 minutes)

* SWI QSM 1.0iso 8 echoes CS 6 (7 minutes)

* SWI QSM 1.0iso 8 echoes CS 9 (5 minutes)

* SWI QSM 1.0iso 8 echoes CS 12 (3 minutes)

Study Timeline

• Study First Submitted: 2021-05-25
• Study First Submitted QC: 2021-05-25
• Study First Posted: 2021-05-28
• Study Start: 2021-12-15
• Status Verified: 2023-07
• Last Update Submitted: 2023-07-25
• Last Update Posted: 2023-07-27
• Primary Completion: 2024-06-27
• Study Completion: 2025-04-27

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

For patients with MS:

• Patient over 18 years old
• Presenting MS defined according to McDonald's revised criteria for spatial and temporal clinical or radiological dissemination [16],
• Should benefit as part of the care of an MRI examination with or without injection of gadolinium
• Express consent to participate in the study
• Affiliate or beneficiary of a social security scheme

For patients with an indication to undergo a brain MRI and at low risk of inflammatory CNS disease:

• Patient over 18 years old
• Should benefit as part of the care of an MRI examination with or without injection of gadolinium
• Express consent to participate in the study
• Affiliate or beneficiary of a social security scheme

Exclusion Criteria

• For patients with MS:
• Patient benefiting from a legal protection measure
• Pregnant or breastfeeding woman

For patients with an indication to undergo a brain MRI and at low risk of inflammatory CNS disease:

• Patient benefiting from a legal protection measure
• Pregnant or breastfeeding woman
• Patient with inflammatory and / or demyelinating pathology of the CNS

Secondary exclusion criteria :

• Motion artefact not allowing interpretation of images
• Patient who did not perform one of the following sequences: 3D T1 TFE, 3D FLAIR (for MS patients), SWI QSM 1.0iso 8 echoes.

Secondarily excluded patients will be replaced.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
concordance of QSM signal with and without compressed-sensing in white matter	1 DAY	concordance of QSM signal with and without compressed-sensing in white matter

Trial Locations

Locations (1)

Hhopital fondation adolphe de rothschild; 🇫🇷 Paris, France