to study the effect of nebulized Dexmedetomidine and Dexamethasone in preventing sore throat following endotracheal intubation

Not yet recruiting

• Conditions: Medical and Surgical, (2) ICD-10 Condition: O||Medical and Surgical,

• Registration Number: CTRI/2021/09/036526
• Lead Sponsor: Dayanand Medical College and Hospital

Brief Summary

Post operative sore throat is experienced by patients during the post operative recovery period following general anaesthesia with endotracheal intubation. Nebulized Dexmedetomidine and Dexamethasone are being used in preventing post operative sore throat but very limited studies have been done to compare the effect of two drugs. Our aim in this study is to compare the effectiveness of nebulized Dexmedetomidine with Dexamethasone in preventing post operative sore throat. A total of 150 patients will be randomly allocated to either of three study groups of 50 patients of either sex each;.≥18 years ; ASA  I-III, undergoing surgery under general anaesthesia with endotracheal intubation will be included in this prospective,double blind ,randomized controlled trial. Exclusion criteria is patients withhistory of recent upper respiratory tract infection or sore throat ,duration of surgery >3 hrs, Mallampati grade ≥3 , patients who need more than two intubation attempts, patient allergic to the drugs used in the study. Patients will be divided into three groups of 50 each ,group a and b are nebulized with Dexmedetomidine and Dexamethasone respectively, group C is control and patients in this group are nebulized with normal saline. Patients will be assessed in the postoperative ward by an anaesthesiologist blinded for the study. Intensity of sore throat, cough, hoarseness and pain will be assessed at 0 hr, 1 hr, 2 hr, 4 hr, 8 hr, 12 hr, 24 hr postoperatively. The severity of POST will be graded. The data thus obtained will be compiled and analysed to reach valid conclusions.

Detailed Description

Not available

Study Timeline

• Study Start: 2021-09-15
• Last Update Posted: 2021-11-09

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 150

Inclusion Criteria

ASA I, II and III patients with age group of ≥18 years undergoing surgery under general anaesthesia with endotracheal intubation.

Exclusion Criteria

1.History of recent upper respiratory tract infection or sore throat 2.Duration of surgery >3 hrs 3.Mallampati grade ≥3 4.Patients who will need more than one intubation attempt •Patient allergic to the drugs used in the study.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To compare role of nebulized Dexmedetomidine with Dexamethasone in preventing Post Operative Sore Throat following endotracheal intubation.	Immediate postoperatively till 24 hours

Secondary Outcome Measures

Name	Time	Method
To assess any other side effects (if any)	24 hours

Trial Locations

Locations (1)

Dayanand Medical College and Hospital; 🇮🇳 Ludhiana, PUNJAB, India

Dayanand Medical College and Hospital

🇮🇳Ludhiana, PUNJAB, India

Dr Gurpreeti Grewal

Principal investigator

9779552017

grewal.preeti@gmail.com