Effects of Prolonged Roll-tilt in Healthy Human Subjects

Not Applicable

• Conditions: Adaptation Reaction

• Registration Number: NCT02980419
• Lead Sponsor: University of Zurich

Brief Summary

The long-term goal of this research is to advance the investigators knowledge of how the brain combines the information of multiple sensory systems coding for spatial oriention and how adaptation to vestibular imbalance influences spatial orientation. In healthy human subjects verticality perception is accurate while upright. After prolonged roll-tilt, humans show a systematic bias in perceived direction towards the previous roll-tilted position (so-called "post-tilt bias"). This effect could either be related to adaptation to the roll-tilted position (shifting the "null" position) or it could be related to changes in torsional eye position due to prolonged static roll-tilt (ocular counter-roll). While in the first case a post-tilt bias is predicted independently of the experimental paradigm used, the second hypothesis predicts a post-tilt bias only if retinal cues are integrated. In order to evaluate these hypotheses, the investigators will assess perceived vertical using both vision-dependent and vision-independent paradigms.

Detailed Description

Not available

Study Timeline

• Study Start: 2016-06
• Study First Submitted: 2016-11-16
• Study First Submitted QC: 2016-11-29
• Study First Posted: 2016-12-02
• Status Verified: 2019-12
• Last Update Submitted: 2020-01-06
• Last Update Posted: 2020-01-07
• Primary Completion: 2020-05-01
• Study Completion: 2020-05-31

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• ages 18-65 years
• informed consent
• absence of exclusion criteria

Exclusion Criteria

• peripheral-vestibular deficit
• disturbed consciousness
• history of sensory deficits
• visual field deficits
• other neurological or systemic disorder which can cause dementia or cognitive dysfunction
• intake of antidepressants, sedatives, or neuroleptics
• pregnancy, unless excluded by a negative pregnancy test
• known neck pain or status post neck trauma

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Primary Outcome Measures

Name	Time	Method
adjustment errors of the subjective visual/haptic/postural vertical in upright position after prolonged whole-body roll-tilt positions.	10 minutes (i.e. short-term adaptation)	the accuracy and precision of visual vertical adjustments after prolonged roll tilt are quantified.

Secondary Outcome Measures

Name	Time	Method
changes in adjustment errors of the subjective visual vertical when providing an additional optokinetic stimulus	10 minutes (i.e. short-term adaptation)	This is the same as in outcome 1, but an additional visual (optokinetic) stimulus is added
changes in adjustment errors of the subjective haptic vertical when providing an additional optokinetic stimulus	10 minutes (i.e. short-term adaptation)	This is the same as in outcome 1, but an additional visual (optokinetic) stimulus is added
changes in adjustment errors of the subjective postural vertical when providing an additional optokinetic stimulus	10 minutes (i.e. short-term adaptation)	This is the same as in outcome 1, but an additional visual (optokinetic) stimulus is added

Trial Locations

Locations (1)

University Hospital Zurich, Dept. of Neurology; 🇨🇭 Zurich, ZH, Switzerland