Comparison of antibiotic-only and antibiotic-steroid combination treatment in corneal ulcer patients: a double-blinded, randomised clinical trial
Completed
- Conditions
- Corneal ulcersEye DiseasesCorneal ulcer
- Registration Number
- ISRCTN71482124
- Lead Sponsor
- Physicians' Services Incorporated Foundation (Canada)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 122
Inclusion Criteria
1. Bacterial corneal ulcer, defined as corneal epithelial defect and stromal inflammation of presumed bacterial origin,that is culture confirmed or gram stain positive
2. Involvement of only one eye
3. Over the age of 12 years
Exclusion Criteria
1. Fungal, viral or amoebic keratitis
2. Known sensitivity or allergy to trial drugs
3. Perforated ulcer
4. Involvement of only functional eye, best corrected visual acuity worse than 20/200 in the uninfected eye
5. Use of topical or systemic steroids concurrently or within the past 2 months
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Residual ulcer size compared to baseline
- Secondary Outcome Measures
Name Time Method 1. Time to healing (days)<br>2. Rate of cure or treatment failure<br>3. Visual acuity<br>4. Quality of life<br>5. Physician Scoring of Ocular symptoms and signs